{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T09:51:04Z","timestamp":1702201864403},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T00:00:00Z","timestamp":1455148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The definition of pulmonary fungal infections (<jats:styled-content style=\"fixed-case\">PFI<\/jats:styled-content>) according to the <jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content> criteria may lack diagnostic sensitivity due to the possible presentation of <jats:styled-content style=\"fixed-case\">PFI<\/jats:styled-content> with different radiological pictures. We evaluated the hypothesis to apply less restrictive radiological criteria to define <jats:styled-content style=\"fixed-case\">PFI<\/jats:styled-content> in patients with acute myeloid leukaemia (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>) submitted to chemotherapy. Overall, 73 consecutive episodes of pulmonary infiltrates associated to positive serum galactomannan test or fungal isolation or galactomannan detection from respiratory specimens were considered. <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scans acquired at the onset of symptoms (time\u20100) and within 4 weeks (time\u20101) were analysed to identify specific (group A) or aspecific radiological signs (group B). Pulmonary infiltrates fulfilled the <jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content> criteria in 49 patients (group A), whereas in 24 patients (group B) they did not reach the criteria due to aspecific <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> findings at time\u20100. Eleven of 21 (52.4%) patients of the group B evaluable for the evolution of the radiological findings fulfilled <jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content> criteria at time\u20101. All the analysed clinical and mycological characteristics, response to antifungal therapy and survival were comparable in the two groups. Our study seems to confirm the possibility to extend the radiological suspicion of <jats:styled-content style=\"fixed-case\">PFI<\/jats:styled-content> to less restrictive chest <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> findings when supported by microbiological criteria in high\u2010risk haematological patients.<\/jats:p>","DOI":"10.1111\/myc.12480","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T12:56:38Z","timestamp":1455195398000},"page":"357-364","source":"Crossref","is-referenced-by-count":6,"title":["Pulmonary fungal infections in patients with acute myeloid leukaemia: is it the time to revise the radiological diagnostic criteria?"],"prefix":"10.1111","volume":"59","author":[{"given":"Francesca","family":"Maccioni","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Radiologiche Azienda Policlinico Umberto I \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Vetere","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Radiologiche Azienda Policlinico Umberto I \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"De Felice","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Radiologiche Azienda Policlinico Umberto I \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najwa","family":"Al Ansari","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Radiologiche Azienda Policlinico Umberto I \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Micozzi","sequence":"additional","affiliation":[{"name":"Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa Azienda Policlinico Umberto I \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Gentile","sequence":"additional","affiliation":[{"name":"Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa Azienda Policlinico Umberto I \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Fo\u00e0","sequence":"additional","affiliation":[{"name":"Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa Azienda Policlinico Umberto I \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Girmenia","sequence":"additional","affiliation":[{"name":"Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa Azienda Policlinico Umberto I \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/517849"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.012054"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.030825"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/323335"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_7_7_1","first-page":"986","article-title":"Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15\u2010year period (1989\u20132003)","volume":"91","author":"Chamilos G","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21755"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2007.00264.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-002-0599-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/657065"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03685.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2011.630040"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32833118fd"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.21.8032"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/590566"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.4.1818-1828.2005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2462070712"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu673"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit929"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/39784231"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12480","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:12:55Z","timestamp":1696482775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,11]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/myc.12480"],"URL":"https:\/\/doi.org\/10.1111\/myc.12480","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,11]]}}}