{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:56:25Z","timestamp":1769604985917,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Unlike bacterial infections, the value of procalcitonin (<jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content>) in detecting fungal infections in leukaemia patients is not clear. To determine whether the monitoring of <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> coupled with C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) and fibrinogen (Fib) could be helpful in the management of pulmonary aspergillosis (<jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>) or mucormycosis (<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>), we retrospectively analysed the evolution of <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CRP<\/jats:styled-content> and Fib levels in 94 leukaemia patients with proven\/probable <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a077) or <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a017) from D\u221212 to D12 relative to <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> onset defined as D0. Overall, 2140 assays were performed. From D\u221212 to D0, 12%, 5% and 1.4% of patients had <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> &gt;0.5, 1 and 1.5\u00a0\u03bcg\u00a0l<jats:sup>\u22121<\/jats:sup>, respectively, while <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> was &gt;50, 75 and 100\u00a0mg\u00a0l<jats:sup>\u22121<\/jats:sup> in 84%, 70% and 57% and Fib was &gt;4, 5 and 6\u00a0g\u00a0l<jats:sup>\u22121<\/jats:sup> in 96%, 80% and 61% of cases respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a010<jats:sup>\u22127<\/jats:sup>). The same trends were observed from D1 to D12. Overall, between D\u221212 and D12, only 6.4% of patients had <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> &gt;1.5\u00a0\u03bcg\u00a0l<jats:sup>\u22121<\/jats:sup>, while <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> &gt;100\u00a0mg\u00a0l<jats:sup>\u22121<\/jats:sup> and Fib &gt;6\u00a0g\u00a0l<jats:sup>\u22121<\/jats:sup> were observed in 80% and 75% of cases respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a010<jats:sup>\u22127<\/jats:sup>). In leukaemia patients, <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> was accompanied by a significant increase in <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and Fib while <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> remained low.<\/jats:p>","DOI":"10.1111\/myc.12487","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T08:20:46Z","timestamp":1456906846000},"page":"383-390","source":"Crossref","is-referenced-by-count":32,"title":["Evolution of procalcitonin, C\u2010reactive protein and fibrinogen levels in neutropenic leukaemia patients with invasive pulmonary aspergillosis or mucormycosis"],"prefix":"10.1111","volume":"59","author":[{"given":"Marjorie","family":"Roques","sequence":"first","affiliation":[{"name":"Department of Clinical Haematology Dijon University Hospital Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Lorraine","family":"Chretien","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Dijon University Hospital Dijon France"},{"name":"Inserm Unit 866 LabEx team Dijon School of Medicine Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Favennec","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Dijon University Hospital Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Lafon","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Dijon University Hospital Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Ferrant","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Dijon University Hospital Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"legouge","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Dijon University Hospital Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia","family":"Plocque","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Dijon University Hospital Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Golfier","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Dijon University Hospital Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Duvillard","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Laboratory Dijon University Hospital Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Amoureux","sequence":"additional","affiliation":[{"name":"Department of Bacteriology Dijon University Hospital Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Noel","family":"Bastie","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Dijon University Hospital Dijon France"},{"name":"Inserm Unit 866 LabEx team Dijon School of Medicine Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lory","family":"Maurin\u2010Bernier","sequence":"additional","affiliation":[{"name":"Department of Biometrics ICTA Fontaine\u2010les\u2010Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Dalle","sequence":"additional","affiliation":[{"name":"Department of Mycology and Parasitology Dijon University Hospital Dijon 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