{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T11:05:06Z","timestamp":1763809506520},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T00:00:00Z","timestamp":1458691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008672","name":"Wilhelm Sander-Stiftung","doi-asserted-by":"publisher","award":["2007.102.1"],"award-info":[{"award-number":["2007.102.1"]}],"id":[{"id":"10.13039\/100008672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Aspergillus fumigatus<\/jats:italic> is an opportunistic mould that causes invasive pulmonary aspergillosis (<jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>), a life\u2010threatening infection in immunocompromised patients. During the course of <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>, localised areas of tissue hypoxia occur. Bacterial infection models revealed that hypoxic microenvironments modulate the function of host immune cells. However, the influence of hypoxia on anti\u2010fungal immunity has been largely unknown. We evaluated the impact of hypoxia on the human anti\u2010<jats:italic>A.\u00a0fumigatus<\/jats:italic> immune response. Human monocyte\u2010derived dendritic cells (<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s) were stimulated <jats:italic>in\u00a0vitro<\/jats:italic> with germ tubes of <jats:italic>A.\u00a0fumigatus<\/jats:italic> under normoxia or hypoxia (1% O<jats:sub>2<\/jats:sub>), followed by analysis of <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> viability, maturation and cytokine release. While <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> viability was unaffected, hypoxia attenuated cytokine release from <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s and maturation of <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s upon stimulation with <jats:italic>A.\u00a0fumigatus<\/jats:italic>. These data suggest that hypoxia at the site of <jats:italic>A.\u00a0fumigatus<\/jats:italic> infection inhibits full activation and function of human <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s. Thereby, this study identified hypoxia as a crucial immune\u2010modulating factor in the human anti\u2010fungal immune response that might influence the course and outcome of <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content> in immunocompromised patients.<\/jats:p>","DOI":"10.1111\/myc.12498","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T11:17:15Z","timestamp":1458731835000},"page":"503-508","source":"Crossref","is-referenced-by-count":21,"title":["Hypoxia attenuates anti\u2010<i>Aspergillus fumigatus<\/i> immune responses initiated by human dendritic cells"],"prefix":"10.1111","volume":"59","author":[{"given":"Mirjam","family":"Fliesser","sequence":"first","affiliation":[{"name":"Medical Clinic and Polyclinic II University Hospital Wuerzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Wallstein","sequence":"additional","affiliation":[{"name":"Medical Clinic and Polyclinic II 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