{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:33:52Z","timestamp":1790714032100,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Invasive fungal infections, usually <jats:italic>Aspergillus<\/jats:italic> and <jats:italic>Candida<\/jats:italic>, represent a major cause of morbidity and mortality in patients with malignant haematological diseases, but in the last years rare fungal infections have more frequently been reported. Here, we report the clinical history of three patients affected with haematological malignancies who developed an infection caused by <jats:italic>Geotrichum<\/jats:italic> (<jats:italic>G<\/jats:italic>.) <jats:italic>clavatum<\/jats:italic>. Two out of three patients were affected by acute myeloid leukaemia (AML), and one by mantle cell lymphoma (MCL). All patients received cytarabine\u2010based chemotherapeutic regimens and developed <jats:italic>G. clavatum<\/jats:italic> infection within 3 weeks from therapy initiation. In all cases, <jats:italic>G. clavatum<\/jats:italic> was isolated from central venous catheter and peripheral blood cultures. <jats:italic>In vitro<\/jats:italic> susceptibility test confirmed an intrinsic resistance to echinocandins and, in all cases, visceral localisations (spleen, liver and lung) were documented by total body computed tomography (CT) scan. A prolonged antifungal therapy with high doses liposomal amphotericin\u2010B was necessary to obtain fever resolution. Only the patient with MCL died while the other two AML recovered, and one of them after received an allogeneic stem cell transplantation. We consecutively reviewed all published cases of infection caused by <jats:italic>G. clavatum<\/jats:italic>. Our experience and literature review indicate that <jats:italic>G. clavatum<\/jats:italic> can cause invasive infection in haematological patients, mainly in those with acute leukaemia.<\/jats:p>","DOI":"10.1111\/myc.12508","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T18:16:02Z","timestamp":1460312162000},"page":"594-601","source":"Crossref","is-referenced-by-count":51,"title":["A cluster of <i>Geotrichum clavatum<\/i> (<i>Saprochaete clavata<\/i>) infection in haematological patients: a first Italian report and review of literature"],"prefix":"10.1111","volume":"59","author":[{"given":"Maria Ilaria","family":"Del Principe","sequence":"first","affiliation":[{"name":"Cattedra di Ematologia Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli studi di Roma \u201cTor Vergata\u201d Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Sarmati","sequence":"additional","affiliation":[{"name":"Clinica di Malattie Infettive Dipartimento di Medicina dei Sistemi Universit\u00e0 Tor Vergata Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariagiovanna","family":"Cefalo","sequence":"additional","affiliation":[{"name":"Cattedra di Ematologia Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli studi di Roma \u201cTor Vergata\u201d Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Fontana","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Chirurgia Universit\u00e0 Tor Vergata Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"De Santis","sequence":"additional","affiliation":[{"name":"Cattedra di Ematologia Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli studi di Roma \u201cTor Vergata\u201d Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Buccisano","sequence":"additional","affiliation":[{"name":"Cattedra di Ematologia Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli studi di Roma \u201cTor Vergata\u201d Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Maurillo","sequence":"additional","affiliation":[{"name":"Cattedra di Ematologia Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli studi di Roma \u201cTor Vergata\u201d Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"De Bellis","sequence":"additional","affiliation":[{"name":"Cattedra di Ematologia Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli studi di Roma \u201cTor Vergata\u201d Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Postorino","sequence":"additional","affiliation":[{"name":"Cattedra di Ematologia Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli studi di Roma \u201cTor Vergata\u201d Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Sconocchia","sequence":"additional","affiliation":[{"name":"Istituto di Farmacologia Translazionale Dipartimento di Medicina CNR Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Del Poeta","sequence":"additional","affiliation":[{"name":"Cattedra di Ematologia Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli studi di Roma \u201cTor Vergata\u201d Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Sanguinetti","sequence":"additional","affiliation":[{"name":"Istituto di Microbiologia Universit\u00e0 Cattolica del Sacro Cuore Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Amadori","sequence":"additional","affiliation":[{"name":"Cattedra di Ematologia Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli studi di Roma \u201cTor Vergata\u201d Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Pagano","sequence":"additional","affiliation":[{"name":"Istituto di Ematologia Universit\u00e0 Cattolica del Sacro Cuore Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Venditti","sequence":"additional","affiliation":[{"name":"Cattedra di Ematologia Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli studi di Roma \u201cTor Vergata\u201d Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"1068","article-title":"The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM\u20102004 study","volume":"91","author":"Pagano L","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_4_3_1","unstructured":"LacroixC.Geotrichum spp. News permanent clinical bacteriology. Section XII Ch 8.2000"},{"key":"e_1_2_4_4_1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1128\/jcm.25.7.1191-1194.1987","article-title":"DNA relatedness, taxonomy and medical significance of Geotrichum capitatum","volume":"25","author":"Gu\u00e9ho E","year":"1987","journal-title":"J Clin Microbiol"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.07.008"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.6490"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304083281404"},{"key":"e_1_2_4_8_1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1200\/JCO.1983.1.11.689","article-title":"High\u2010dose cytosine arabinoside in non Hodgkin' s lymphoma","volume":"1","author":"Kantarijan H","year":"1983","journal-title":"J Clin Oncol"},{"key":"e_1_2_4_9_1","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE)Version 4.0 Published: May 28 2009(v4.03: June 14 2010).U.S.Department of Health And Human Services."},{"key":"e_1_2_4_10_1","unstructured":"National Committee for Clinical Laboratory Standards.Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved standard. Document M27\u2010A3.Villanova Pa:National Committee for Clinical Laboratory Standards;2008"},{"key":"e_1_2_4_11_1","unstructured":"Antifungal Susceptibility Testing: Clinical Laboratory and Standards Institute (CLSI) MethodsM27\u2010S4 (2012)."},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02309-14"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.820290"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-014-9746-4"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.4.1818-1828.2005"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00039-14"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-013-0319-9"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200304"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/380643"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/11.Supplement_7.S1591"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/514731"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780500474327"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2011.09.017"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70218-8"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000235"},{"key":"e_1_2_4_26_1","first-page":"179","article-title":"Effect of tissue penetration on AmBisome efficacy","volume":"4","author":"Adler\u2010Moore J","year":"2003","journal-title":"Curr Opinion Invest Drugs"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12360"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12508","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T14:48:10Z","timestamp":1696258090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,8]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/myc.12508"],"URL":"https:\/\/doi.org\/10.1111\/myc.12508","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,8]]}}}