{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:35:50Z","timestamp":1761129350579},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007054","name":"Meso Scale Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004324","name":"Astellas Pharma US","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The low incidence of mixed candidaemia (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>) may have precluded a better knowledge of its clinical presentation. The aim of the study was to analyse the risk factors, clinical presentation and prognosis of <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> episodes. A comparison between <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> and monomicrobial candidaemia within a prospective programme on candidaemia was performed in 29 hospitals between April 2010 and May 2011. In fifteen episodes of candidaemia corresponding to 15 patients, out of 752, two species of <jats:italic>Candida<\/jats:italic> (1.9%) were isolated. <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> was more frequent in patients with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection (12%, <jats:italic>P<\/jats:italic> = 0.038) and those admitted due to extensive burns (23%, <jats:italic>P<\/jats:italic> = 0.012). The <jats:italic>Candida<\/jats:italic> species most frequently identified in <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> were <jats:italic>C. albicans<\/jats:italic> 12 patients (40%), <jats:italic>C. glabrata<\/jats:italic> seven patients (23.3%) and <jats:italic>C. parapsilosis<\/jats:italic> six patients (20%). Early mortality was higher (nine patients, 60%) in patients with <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> than in patients with <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> (223 patients, 30.3%, <jats:italic>P<\/jats:italic> = 0.046). In conclusion, MC was was independently associated with increased mortality even after considering other prognostic factors. <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> is an infrequent event that is more common in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection and in patients suffering from burns, and is associated with increased mortality.<\/jats:p>","DOI":"10.1111\/myc.12516","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T10:13:29Z","timestamp":1469096009000},"page":"636-643","source":"Crossref","is-referenced-by-count":7,"title":["Risk factors, clinical presentation and prognosis of mixed candidaemia: a population\u2010based surveillance in Spain"],"prefix":"10.1111","volume":"59","author":[{"given":"Antonio","family":"Ramos","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit (MI) Hospital Universitario Puerta de Hierro Majadahonda Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Romero","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Hospital Universitario Puerta de Hierro Majadahonda Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"S\u00e1nchez\u2010Romero","sequence":"additional","affiliation":[{"name":"Microbiology Department Hospital Universitario Puerta de Hierro Majadahonda Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Fort\u00fan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital Universitario Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ram\u00f3n","family":"Pa\u00f1o","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital Universitario La Paz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Pem\u00e1n","sequence":"additional","affiliation":[{"name":"Microbiology Department Hospital Universitario la Fe Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merc\u00e8","family":"Gurgu\u00ed","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital de la Santa Creu i Sant Pau and Instituto de Investigaci\u00f3n Biom\u00e9dica Sant Pau Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Rodr\u00edguez\u2010Ba\u00f1o","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital Universitario Virgen Macarena Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"Padilla","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/520192"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199104113241511"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1177\/000313481107700824","article-title":"Central line associated blood stream infection in the critically ill trauma patient","volume":"77","author":"Smith JW","year":"2011","journal-title":"Am Surg"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20573"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/518175"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(02)00460-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/11.2.208"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12380"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.4.1829-1835.2005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1644"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03880.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02155-13"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.5.1169-1175.1998"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.8.1923-1929.1994"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt256"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00265-13"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402473"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.5359"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2004.16.2.172"},{"key":"e_1_2_8_23_1","first-page":"2","article-title":"Candidemia in AIDS. A retrospective study of nine cases","volume":"17","author":"Saballs\u2010Radresa P","year":"2000","journal-title":"Rev Iberoam Micol"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2011.03759.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/108729101316914403"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02447924"},{"key":"e_1_2_8_27_1","first-page":"336","article-title":"Candida albicans\u2013Staphylococcus aureus polymicrobial peritonitis modulates host innate immunity","volume":"21","author":"Peters BM","year":"2014","journal-title":"Anesthesiology"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201211-1967OC"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.5.3218"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762005000500014"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.70718"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12539"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-013-0432-0"},{"key":"e_1_2_8_34_1","first-page":"99","article-title":"Candidemia combined with bacterial bloodstream infection: analysis of clinical features and associated risk factors","volume":"37","author":"Liu Y","year":"2014","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05474-11"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1086\/651262"},{"key":"e_1_2_8_37_1","first-page":"493","article-title":"Candidemia at selected Canadian sites: results from the Fungal Disease Registry, 1992\u20131994. Fungal Disease Registry of the Canadian Infectious Disease Society","volume":"160","author":"Yamamura DL","year":"1999","journal-title":"CMAJ"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12516","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:42:22Z","timestamp":1696207342000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,21]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/myc.12516"],"URL":"https:\/\/doi.org\/10.1111\/myc.12516","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,21]]}}}