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We investigated the clinical effects of intravenous voriconazole formulated with sulfobutylether \u03b2\u2010cyclodextrin (<jats:styled-content style=\"fixed-case\">SBECD<\/jats:styled-content>) in patients with renal impairment. A prospective observational study was conducted on 25 adult patients with haematological malignancies who were treated with intravenous voriconazole for invasive aspergillosis. Among them, seven patients had a baseline creatinine clearance (CrCl) &lt;50 ml min<jats:sup>\u22121<\/jats:sup>(case). Although voriconazole trough concentrations were significantly higher in cases (5.84 mg l<jats:sup>\u22121<\/jats:sup>) than controls (2.28 mg l<jats:sup>\u22121<\/jats:sup>), the proportion of concentrations within the target range did not differ between two groups (4\/7 and 12\/18, respectively;<jats:italic>P<\/jats:italic>= 0.658). The frequency of severe adverse events in cases (3\/7) was comparable to that of controls (4\/18;<jats:italic>P<\/jats:italic>= 0.355). No patients showed significant deterioration in renal function after the voriconazole therapy even in patients with renal impairment. Although CrCl &lt;50 ml min<jats:sup>\u22121<\/jats:sup>was associated with higher voriconazole concentrations, its clinical impact remains unclear.<jats:styled-content style=\"fixed-case\">SBECD<\/jats:styled-content>\u2010formulated intravenous voriconazole did not lead to a higher incidence of severe adverse events including nephrotoxicity in haematological patients with CrCl &lt;50 ml min<jats:sup>\u22121<\/jats:sup>.<\/jats:p>","DOI":"10.1111\/myc.12517","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T08:57:23Z","timestamp":1466585843000},"page":"644-651","source":"Crossref","is-referenced-by-count":36,"title":["Therapeutic drug monitoring and safety of intravenous voriconazole formulated with sulfobutylether \u03b2\u2010cyclodextrin in haematological patients with renal impairment"],"prefix":"10.1111","volume":"59","author":[{"given":"Si\u2010Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea"},{"name":"Vaccine Bio Research Institute College of Medicine The Catholic University of Korea Seoul Korea"},{"name":"Division of Infectious Diseases Department of Internal Medicine College of Medicine The Catholic University of Korea Incheon St. Mary's Hospital Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Cheol","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea"},{"name":"Vaccine Bio Research Institute College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chulmin","family":"Park","sequence":"additional","affiliation":[{"name":"Vaccine Bio Research Institute College of Medicine The Catholic University of Korea Seoul 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