{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:09:33Z","timestamp":1788923373431,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The burden of histoplasmosis has been poorly documented in most of the endemic areas for the disease, including Brazil. Also, modern non\u2010culture\u2010based diagnostic tests are often non\u2010available in these regions. This was a prospective cohort study in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients with suspected disseminated disease evaluated with different diagnostic tests. Patients were enrolled in three referral medical centres in Porto Alegre, Brazil. Among 78 evaluated patients, disseminated histoplasmosis was confirmed in eight individuals (10.3%) by the means of classical (culture\/histopathology) tests. Antigen detection in the urine was found to be more sensitive: <jats:styled-content style=\"fixed-case\">IMMY<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> <jats:styled-content style=\"fixed-case\">ALPHA ELISA<\/jats:styled-content> detected 13 positive cases (16.7%) and the in\u2010house <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> test developed by the Centers for Disease Prevention and Control (<jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content>) detected 14 (17.9%). <jats:styled-content style=\"fixed-case\">IMMY<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> and <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content> tests provided concordant results in 96.2% of cases. This is the first study to compare the performance of the in\u2010house <jats:styled-content style=\"fixed-case\">CDC ELISA<\/jats:styled-content> test with the IMMY<jats:sup>\u00ae<\/jats:sup> commercial test for the diagnosis of histoplasmosis, and a high degree of concordance was observed. The study revealed that <jats:italic>H. capsulatum<\/jats:italic> is an important agent of disseminated disease in <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> patients in Brazil, reinforcing the importance of making available modern diagnostic tests as well as safer antifungal agents for the treatment of histoplasmosis.<\/jats:p>","DOI":"10.1111\/myc.12536","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T05:16:13Z","timestamp":1469164573000},"page":"20-24","source":"Crossref","is-referenced-by-count":22,"title":["Disseminated histoplasmosis and <scp>AIDS<\/scp>: a prospective and multicentre study to evaluate the performance of different diagnostic tests"],"prefix":"10.1111","volume":"60","author":[{"given":"E. R.","family":"Hoffmann","sequence":"first","affiliation":[{"name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA) Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. C.","family":"Daboit","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA) Porto Alegre Brazil"},{"name":"Universidade Federal do Piau\u00ed (UFPI) Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. D.","family":"Paskulin","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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