{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:29:29Z","timestamp":1793039369391,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T00:00:00Z","timestamp":1471219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Few studies have evaluated the utility of <jats:italic>Aspergillus fumigatus<\/jats:italic>\u2010specific IgG in allergic bronchopulmonary aspergillosis (<jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content>). Herein, we evaluate the role of specific IgG in diagnosis and monitoring treatment response in <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content>. Forty\u2010eight control subjects with <jats:italic>A.\u00a0fumigatus<\/jats:italic>\u2010associated asthma underwent <jats:italic>A.\u00a0fumigatus<\/jats:italic>\u2010specific IgG measurements at baseline, while specific IgG was assayed in 102 treatment\u2010na\u00efve subjects of <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> at baseline, after eight weeks of glucocorticoid therapy, and during exacerbations. For determining the cut\u2010off of <jats:italic>A.\u00a0fumigatus<\/jats:italic>\u2010specific IgG, we randomly classified two\u2010thirds of the study subjects (cases and controls) as the derivation cohort, while the remaining one\u2010thirds were labelled as the validation cohort. The best cut\u2010off value of <jats:italic>A.\u00a0fumigatus<\/jats:italic>\u2010specific IgG in the derivation cohort was 26.9\u00a0mg<jats:sub>A<\/jats:sub>\/L (sensitivity: 88%; specificity: 100%). Using this limit, the sensitivity and specificity of <jats:italic>A.\u00a0fumigatus<\/jats:italic>\u2010specific IgG in diagnosis of <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> was 89% and 100%, respectively, in the validation cohort. In contrast, the sensitivity of <jats:italic>Aspergillus<\/jats:italic> precipitins was only 27.4%. Following treatment, the <jats:italic>A.\u00a0fumigatus<\/jats:italic>\u2010specific IgG increased in 38 (37.2%) subjects, while it decreased in three (23.1%) of the 13 subjects experiencing an exacerbation. The <jats:italic>A.\u00a0fumigatus<\/jats:italic>\u2010specific IgG was found to be an extremely useful test in the diagnosis and differential diagnosis of <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> but is unreliable in monitoring treatment response in this disorder.<\/jats:p>","DOI":"10.1111\/myc.12541","type":"journal-article","created":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T06:12:48Z","timestamp":1471241568000},"page":"33-39","source":"Crossref","is-referenced-by-count":78,"title":["Role of <i>Aspergillus fumigatus<\/i>\u2010specific IgG in diagnosis and monitoring treatment response in allergic bronchopulmonary aspergillosis"],"prefix":"10.1111","volume":"60","author":[{"given":"Ritesh","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh 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