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Using a murine model of systemic infection by these fungi, we have evaluated the efficacy of amphotericin B (<jats:styled-content style=\"fixed-case\">AMB<\/jats:styled-content>) at 0.8\u00a0mg\/kg, administered intravenously, fluconazole (<jats:styled-content style=\"fixed-case\">FLC<\/jats:styled-content>) or voriconazole (<jats:styled-content style=\"fixed-case\">VRC<\/jats:styled-content>), both administered orally, at 25\u00a0mg\/kg and the combination of <jats:styled-content style=\"fixed-case\">AMB<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">VRC<\/jats:styled-content> against three <jats:italic>C.\u00a0albidus<\/jats:italic> and two <jats:italic>C.\u00a0laurentii<\/jats:italic> strains. All the treatments significantly reduced the fungal burden in all the organs studied. The combination showed a synergistic effect in the reduction in fungal load, working better than both monotherapies. The histopathological study confirmed the efficacy of the treatments.<\/jats:p>","DOI":"10.1111\/myc.12569","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T15:07:58Z","timestamp":1475852878000},"page":"112-117","source":"Crossref","is-referenced-by-count":3,"title":["Combined antifungal therapy against systemic murine infections by rare <i>Cryptococcus<\/i> species"],"prefix":"10.1111","volume":"60","author":[{"given":"Pamela","family":"Thomson","sequence":"first","affiliation":[{"name":"Unitat de Microbiologia Facultat de Medicina i Ci\u00e8ncies de la Salut IISPV; Universitat Rovira i Virgili Reus Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Mayayo","sequence":"additional","affiliation":[{"name":"Unitat d'Anatomia Patol\u00f2gica Facultat de Medicina i Ci\u00e8ncies de la Salut IISPV; Universitat Rovira i Virgili Reus Tarragona 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