{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:31:36Z","timestamp":1790685096627,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T00:00:00Z","timestamp":1481068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004324","name":"Astellas Pharma US","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Recently, mycetoma was added to the World Health Organization's list of neglected tropical disease priorities. <jats:italic>Fusarium<\/jats:italic> as a genus has been reported to cause eumycetoma, but little is known about the species involved in this infection and their identification. In this study, molecular tools were applied to identify <jats:italic>Fusarium<\/jats:italic> agents from human eumycetoma cases. The partial translation elongation factor 1\u2010alpha (<jats:italic><jats:styled-content style=\"fixed-case\">TEF<\/jats:styled-content>\u20101<\/jats:italic>\u03b1) gene was used as diagnostic parameter. Two additional cases of eumycetoma, due to <jats:italic>F.\u00a0keratoplasticum<\/jats:italic> and <jats:italic>F.\u00a0pseudensiforme<\/jats:italic>, respectively, are presented. A systematic literature review was performed to assess general features, identification, treatment and outcome of eumycetoma infections due to <jats:italic>Fusarium<\/jats:italic> species. Of the 20 reviewed patients, the majority (75%) were male. Most agents belonged to the <jats:italic>F.\u00a0solani<\/jats:italic> species complex, ie <jats:italic>F.\u00a0keratoplasticum<\/jats:italic>,<jats:italic> F.\u00a0pseudensiforme<\/jats:italic>, and an undescribed lineage of <jats:italic>F.\u00a0solani<\/jats:italic>. In addition, <jats:italic>F.\u00a0thapsinum,<\/jats:italic> a member of <jats:italic>Fusarium fujikuroi<\/jats:italic> species complex was encountered. The main antifungal drugs used were itraconazole, ketoconazole and amphotericin B, but cure rates were low (15%). Partial response or relapse was observed in some cases, and a case ended in amputation. Clinical management of eumycetoma due to <jats:italic>Fusarium<\/jats:italic> is complex and combination therapy might be required to increase cure rates.<\/jats:p>","DOI":"10.1111\/myc.12590","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T02:33:22Z","timestamp":1481164402000},"page":"204-212","source":"Crossref","is-referenced-by-count":37,"title":["<i>Fusarium<\/i> species causing eumycetoma: Report of two cases and comprehensive review of the literature"],"prefix":"10.1111","volume":"60","author":[{"given":"Abdullah M. S.","family":"Al\u2010Hatmi","sequence":"first","affiliation":[{"name":"CBS\u2010KNAW Fungal Biodiversity Centre  Utrecht The Netherlands"},{"name":"Institute of Biodiversity and Ecosystem Dynamics University of Amsterdam  Amsterdam The Netherlands"},{"name":"Directorate General of Health Services Ibri Hospital Ministry of Health  Muscat Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandro","family":"Bonifaz","sequence":"additional","affiliation":[{"name":"Hospital General de M\u00e9xico, O.D  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Tirado\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Hospital General de M\u00e9xico, O.D  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques F.","family":"Meis","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases Canisius Wilhelmina Hospital (CWZ)  Nijmegen The Netherlands"},{"name":"Centre of Expertise in Mycology Radboudumc\/CWZ  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Sybren","family":"de Hoog","sequence":"additional","affiliation":[{"name":"CBS\u2010KNAW Fungal Biodiversity Centre  Utrecht The Netherlands"},{"name":"Institute of Biodiversity and Ecosystem Dynamics University of Amsterdam  Amsterdam The Netherlands"},{"name":"Basic Pathology Department Federal University of Paran\u00e1 State  Curitiba Brazil"},{"name":"Biology Department Faculty of Science King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0155-8113","authenticated-orcid":false,"given":"Sarah A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Faculty of Medical Laboratory Sciences University of Khartoum  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3767\/003158514X684744"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(15)30353-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.52985"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)01131-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003102"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002550"},{"key":"e_1_2_7_9_1","unstructured":"AhmedSA.New insights into a disfiguring fungal disease eumycetoma. PhD. Thesis University of Amsterdam. 2015.http:\/\/dare.uva.nl\/document\/2\/168941. Accessed on 30 November 2016."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03447.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1993.tb00694.x"},{"key":"e_1_2_7_12_1","first-page":"61","article-title":"Mycetoma: report of 3 cases in Falcon State, Venezuela","volume":"37","author":"P\u00e9rez\u2010Blanco M","year":"1996","journal-title":"Invest Clin"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2011.00783.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005464"},{"key":"e_1_2_7_15_1","first-page":"31","article-title":"Segretain G Mycetomes a Fusarium","volume":"1","author":"Peloux Y","year":"1966","journal-title":"Bull Soc Fr Mycol Med"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.82490"},{"key":"e_1_2_7_17_1","unstructured":"deHoogGS GuarroJ FiguerasMJ Gen\u00e9J.Atlas of clinical fungi 3rd CD\u2010ROM ed CBS\u2010KNAW Fungal Biodiversity Centre Utrecht: \/ Universitat Rovira I Virgili Reus 2009."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00162306"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2013.06.004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015294117574"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.4.1805-1808.2003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.funbio.2015.08.001"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-014-0588-y"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:EJPP.0000032386.75915.a0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00989-10"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst197"},{"key":"e_1_2_7_27_1","unstructured":"Clinical and Laboratory Standards Institute Reference method for broth dilution antifungal susceptibility testing of filamentous fungi Second Edition: Approved Standard. M38\u2010A2. CLSI Wayne PA USA 2008."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200112000-00022"},{"key":"e_1_2_7_29_1","first-page":"2056","article-title":"Mycetoma of the foot; a diseases from the tropics","volume":"137","author":"Klokke AH","year":"1993","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102014\u2010204253"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02059.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1993.tb00693.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1984.tb02022.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1983.01650320081024"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247578"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.110852"},{"key":"e_1_2_7_37_1","first-page":"261","article-title":"Madura's foot (mycetoma)","volume":"98","author":"Mercut D","year":"2003","journal-title":"Chirurgia (Bucur)"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90437-9"},{"key":"e_1_2_7_39_1","first-page":"55","article-title":"Micetoma podal por Fusarium solani (Mart.). Appel & Wollenweber","volume":"6","author":"Luque AG","year":"1991","journal-title":"Bolet\u00edn Micol\u00f3gico"},{"key":"e_1_2_7_40_1","first-page":"2062","article-title":"Mycetomas in the Republic of Somalia","volume":"263","author":"Destombes P","year":"1966","journal-title":"C R Acad Sci Hebd Seances Acad Sci D"},{"key":"e_1_2_7_41_1","first-page":"397","article-title":"Madura's foot in a renal transplant patient: report of a case","volume":"4","author":"Callebaut G","year":"2011","journal-title":"NDT Plus"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rce.2010.06.019"},{"key":"e_1_2_7_43_1","first-page":"93","article-title":"Un caso de eumicetoma por Fusarium oxysporum y su tratamiento con itraconazol","volume":"1","author":"Ochoa MT","year":"1992","journal-title":"Rev Soc Col Dermatol"},{"key":"e_1_2_7_44_1","first-page":"1191","article-title":"New cases of mycetoma detected in Cameroun","volume":"57","author":"Gamet A","year":"1964","journal-title":"Bull Soc Pathol Exot Filiales"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02456-15"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2002.00915.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01470-12"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00248-014-0494-2"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.3852\/15-255"},{"key":"e_1_2_7_50_1","first-page":"e33","article-title":"Global molecular epidemiology and genetic diversity of Fusarium, a significant emerging human opportunist from 1958\u20132015","volume":"5","author":"Al\u2010Hatmi AM","year":"2015","journal-title":"Emerg Microbes Infect"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.funbio.2015.08.006"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(82)90121-3"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12422"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003679"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12465"},{"key":"e_1_2_7_56_1","first-page":"1068","article-title":"Specific antifungal susceptibility profiles of opportunists in the Fusarium fujikuroi complex","volume":"70","author":"Al\u2010Hatmi AMS","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myu098"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv421"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:52:33Z","timestamp":1696225953000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,7]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/myc.12590"],"URL":"https:\/\/doi.org\/10.1111\/myc.12590","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,7]]}}}