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Although the current focus remains on exploring the ways of enhancing permeation through the formidable nail barrier, the understanding of the nail microstructure and composition is far from complete. This article reviews our current understanding of the nail microstructure, composition and diseases. A few of the parameters affecting the nail permeability and potential causes of the recurrence of fungal nail infection are also discussed.<\/jats:p>","DOI":"10.1111\/myc.12592","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T11:40:34Z","timestamp":1484739634000},"page":"284-295","source":"Crossref","is-referenced-by-count":119,"title":["Understanding the formidable nail barrier: A review of the nail microstructure, composition and diseases"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4828-6856","authenticated-orcid":false,"given":"Sudhir","family":"Baswan","sequence":"first","affiliation":[{"name":"James L. 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