{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:17:47Z","timestamp":1791407867539,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Saprochaete<\/jats:italic> and <jats:italic>Geotrichum<\/jats:italic> spp. are rare emerging fungi causing invasive fungal diseases in immunosuppressed patients and scarce evidence is available for treatment decisions. Among 505 cases of rare <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> from the FungiScope<jats:sup>\u2122<\/jats:sup> registry, we identified 23 cases of invasive infections caused by these fungi reported from 10 countries over a 12\u2010year period. All cases were adults and previous chemotherapy with associated neutropenia was the most common co\u2010morbidity. Fungaemia was confirmed in 14 (61%) cases and deep organ involvement included lungs, liver, spleen, central nervous system and kidneys. Fungi were <jats:italic>S.\u00a0capitata<\/jats:italic> (n=14), <jats:italic>S.\u00a0clavata<\/jats:italic> (n=5), <jats:italic>G.\u00a0candidum<\/jats:italic> (n=2) and <jats:italic>Geotrichum<\/jats:italic> spp. (n=2). Susceptibility was tested in 16 (70%) isolates. All <jats:italic>S.\u00a0capitata<\/jats:italic> and <jats:italic>S.\u00a0clavata<\/jats:italic> isolates with the exception of one <jats:italic>S.\u00a0capitata<\/jats:italic> (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> 4\u00a0mg\/L) isolate had <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s&gt;32\u00a0mg\/L for caspofungin. For micafungin and anidulafungin, <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s varied between 0.25 and &gt;32\u00a0mg\/L. One case was diagnosed postmortem, 22 patients received targeted treatment, with voriconazole as the most frequent first line drug. Overall mortality was 65% (n=15). Initial echinocandin treatment was associated with worse outcome at day 30 when compared to treatment with other antifungals (amphotericin B \u00b1 flucytosine, voriconazole, fluconazole and itraconazole) (<jats:italic>P<\/jats:italic>=.036). Echinocandins are not an option for these infections.<\/jats:p>","DOI":"10.1111\/myc.12595","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T09:19:17Z","timestamp":1486027157000},"page":"273-279","source":"Crossref","is-referenced-by-count":93,"title":["Invasive infections due to <i>Saprochaete<\/i> and <i>Geotrichum<\/i> species: Report of 23 cases from the FungiScope Registry"],"prefix":"10.1111","volume":"60","author":[{"given":"Luisa","family":"Dur\u00e1n Graeff","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department I of Internal Medicine University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danila","family":"Seidel","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department I of Internal Medicine University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J. G. T.","family":"Vehreschild","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department I of Internal Medicine University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Hamprecht","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupma","family":"Kindo","sequence":"additional","affiliation":[{"name":"Department of Microbiology Sri Ramachandra Medical College and Research Institute  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenek","family":"Racil","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology and Oncology Masaryk University and University Hospital Brno  Brno Czech 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Immunology and Hygiene University Hospital of Cologne  Cologne Germany"},{"name":"Laboratory Dr. Wisplinghoff  Cologne Germany"},{"name":"Institute for Virology and Medical Microbiology University Witten\/Herdecke  Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-3137","authenticated-orcid":false,"given":"Oliver A.","family":"Cornely","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department I of Internal Medicine University Hospital Cologne  Cologne Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD)  Cologne Germany"},{"name":"German Centre for Infection Research Partner Site Bonn\u2010Cologne  Cologne Germany"},{"name":"Clinical Trials Centre Cologne ZKS K\u00f6ln  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"FungiScope 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