{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:02:17Z","timestamp":1776380537502,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T00:00:00Z","timestamp":1485302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["91\u201001\u201001\u20105510"],"award-info":[{"award-number":["91\u201001\u201001\u20105510"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pityriasis versicolor (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>) is a common superficial fungal disease. Possibility of emergence of resistant strains to azoles, and difficulty in differentiation of hypopigmented <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and early vitiligo, encouraged us to evaluate the efficacy of topical tacrolimus (a calcineurin inhibitor agent with proven in vitro anti\u2010Malassezia effect) for <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> treatment generally and its effect on <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>\u2010induced hypopigmentation specifically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy of topical tacrolimus on pityriasis versicolor. Patients\/Methods: Fifty <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> patients were randomly allocated into two equal groups applying either topical clotrimazol or tacrolimus twice daily for 3\u00a0weeks. They were evaluated at the beginning of study, in the third and fifth weeks clinically and mycologically (direct smear).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although both treatments resulted in global, clinical, and mycological cure of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>, there was no significant difference regarding the mentioned aspects of cure between tacrolimus and clotrimazole treated patients. (<jats:italic>P<\/jats:italic>\u2010value: .63, .45, and .26, respectively) Tacrolimus had no significant effect on hypopigmentation in the fifth week follow\u2010up. (<jats:italic>P<\/jats:italic>\u2010value: .62).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In spite of the lack of efficacy of tacrolimus on <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>\u2010induced hypopigmentation, the therapeutic effect on <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> introduces tacrolimus as a therapeutic option for <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>, especially when early vitiligo is among the differential diagnoses without concerning the aggravating effect of topical corticosteroids on <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.12598","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T07:27:04Z","timestamp":1485329224000},"page":"338-342","source":"Crossref","is-referenced-by-count":9,"title":["Comparative efficacy of topical application of tacrolimus and clotrimazole in the treatment of pityriasis versicolor: A single blind, randomised clinical trial"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8773-0019","authenticated-orcid":false,"given":"Mozhdeh","family":"Sepaskhah","sequence":"first","affiliation":[{"name":"Molecular Dermatology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam Sadat","family":"Sadat","sequence":"additional","affiliation":[{"name":"Molecular Dermatology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7809-4690","authenticated-orcid":false,"given":"Keyvan","family":"Pakshir","sequence":"additional","affiliation":[{"name":"Basic Sciences in Infectious Diseases Research Center Department of Parasitology and Mycology School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Faculty of Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00021-11"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.1.21-57.2002"},{"key":"e_1_2_7_4_1","first-page":"574","article-title":"Treatment of tinea versicolor with a new antifungal agent, ciclopirox olamine cream 1%","volume":"7","author":"Cullen SI","year":"1985","journal-title":"Clin Ther"},{"key":"e_1_2_7_5_1","first-page":"86","article-title":"Comparative study of ketoconazole versus selenium sulphide shampoo in pityriasis versicolor","volume":"69","author":"Aggarwal 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