{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:03:46Z","timestamp":1765807426029,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To study the pathogenicity of <jats:italic>Conidiobolus coronatus<\/jats:italic> (<jats:italic>C.\u00a0coronatus<\/jats:italic>) and <jats:italic>Fusarium solani<\/jats:italic> (<jats:italic>F.\u00a0solani<\/jats:italic>) in animal models. Immunocompromised mice were treated with cyclophosphamide and prednisolone via intraperitoneal injection before and after inoculation. According to pathogenic characteristics of different fungi, <jats:italic>C.\u00a0coronatus was used to infect mice<\/jats:italic> via intravenous inoculation, intraperitoneal inoculation, gastrointestinal infusion and intradermal inoculation methods. And <jats:italic>F.\u00a0solani<\/jats:italic> was used to infect mice by inoculation via the abraded or normal skin. In the group of immunocompromised mice, <jats:italic>C.\u00a0coronatus<\/jats:italic> was isolated from the lung tissues of one mouse on day 7 and another on day 10 respectively. The corresponding histopathology revealed infiltration of local inflammatory cells in the lung tissue. Pathogenic lesions were observed in all normal and immunocompromised mice infected with <jats:italic>F.\u00a0solani<\/jats:italic> via abraded skin. The lesions in the immunocompromised mice were more severe and persisted longer than those in the normal mice. Moreover, hyphae were mostly observed in the histopathological examination and fungal culture from the immunocompromised mouse. The pathogenicity of <jats:italic>C.\u00a0coronatus<\/jats:italic> was relatively weak as it did not induce local infections and did not disseminate the disease in immunocompetent and immunocompromised mice. Therefore, <jats:italic>F.\u00a0solani<\/jats:italic> is a type of opportunistic pathogenic fungus, and abraded skin is one of the causative routes of infection.<\/jats:p>","DOI":"10.1111\/myc.12607","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T05:56:44Z","timestamp":1488175004000},"page":"394-401","source":"Crossref","is-referenced-by-count":5,"title":["Pathogenicity of <i>Conidiobolus coronatus<\/i> and <i>Fusarium solani<\/i> in mouse models"],"prefix":"10.1111","volume":"60","author":[{"given":"Yadi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weifang People's Hospital  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suying","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7644-1828","authenticated-orcid":false,"given":"Xiumin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"442","article-title":"Entomophthoromycosis caused by Conidiobolus coronatus","volume":"39","author":"Xiumin Yang YW","year":"2006","journal-title":"Chinese J Dermatol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.04.032"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2009.01716.x"},{"key":"e_1_2_7_5_1","unstructured":"CLSI.Reference method for broth dilution antifungal susceptibility testing of filamentous fungi Approved standard M38\u2010A National Committee for Clinical Laboratory Standards Wayne Pa. 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