{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:30:29Z","timestamp":1787985029740,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Pulmonary mucormycosis (\n                    <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\n                    ) is a life\u2010threatening infection and the diagnosis can be challenging. The objective was to retrospectively explore the value of the\n                    <jats:styled-content style=\"fixed-case\">RHS<\/jats:styled-content>\n                    in our cohort of 27 patients with mucormycosis and its relation to neutropenia. This was a retrospective study including all patients with a diagnosis of probable or proven invasive\n                    <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\n                    according to the 2008\n                    <jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content>\n                    criteria between September 2003 to April 2016. Fisher's exact test and Mann\u2010Whitney test, with a\n                    <jats:italic>P<\/jats:italic>\n                    \u2010value statistically significant under .05 (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.05), were used to compare neutropenic and non\u2010neutropenic groups. 27 patients were eligible. The\n                    <jats:styled-content style=\"fixed-case\">RHS<\/jats:styled-content>\n                    could be identified in 78% of cases in the neutropenic group, and was less common in the non\u2010neutropenic group (31%) (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.05). Reticulations inside ground\u2010glass opacity in case of\n                    <jats:styled-content style=\"fixed-case\">RHS<\/jats:styled-content>\n                    were present in 13 out of 15 patients (87%).\n                    <jats:italic>Mucorales<\/jats:italic>\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    detection by\n                    <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                    on serum provided, a median time to the first\n                    <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                    \u2010positive sample of 3\u00a0days (\u221233 to +60\u00a0days) before diagnosis was confirmed. Six patients had\n                    <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>\n                    co\u2010infection. In conclusion,\n                    <jats:styled-content style=\"fixed-case\">RHS<\/jats:styled-content>\n                    is more frequent in case of\n                    <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\n                    in neutropenic patients compare to non\u2010neutropenic patients. Its presence in immunocompromised patients should be sufficient to promptly start\n                    <jats:italic>Mucorales<\/jats:italic>\n                    \u2010active antifungal treatment, while its absence especially in non\u2010neutropenic cases should not be sufficient to exclude the diagnosis.\n                  <\/jats:p>","DOI":"10.1111\/myc.12624","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T06:32:57Z","timestamp":1492756377000},"page":"526-533","source":"Crossref","is-referenced-by-count":48,"title":["Prevalence of the reversed halo sign in neutropenic patients compared with non\u2010neutropenic patients: Data from a single\u2010centre study involving 27 patients with pulmonary mucormycosis (2003\u20102016)"],"prefix":"10.1111","volume":"60","author":[{"given":"Jessie","family":"Bourcier","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie Clinique Centre d'Investigation Clinique en Canc\u00e9rologie (CI2C) 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