{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:44:12Z","timestamp":1760028252175,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004385","name":"Universiteit Gent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Invasive aspergillosis(<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>) is a potentially lethal complication of <jats:italic>Aspergillus<\/jats:italic> infection affecting mainly immunocompromised hosts; however, during the last two decades its incidence was increasingly observed in critically ill immunocompetent patients. The objective of this study is to describe the clinical characteristics of histologically proven endomyocardial and pericardial invasion, in the context of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>, in critically ill patients. Eight critically ill patients with histopathological confirmation of endomyocardial\/pericardial aspergillosis were evaluated. Risk factors, clinical and laboratory characteristics, treatment, histopathological characteristics and mortality were recorded. Signs and symptoms of cardiac dysfunction were not observed in any of the patients. Therapy was administered to six of them shortly after the first positive culture. The observed histopathological lesions included haemorrhagic lesions, small vessels with central thrombosis and surrounding consolidated tissue with necrosis. Voriconazole, caspofungin, lipid amphotericin B and itraconazole were the used antifungals. The mortality rate was high (87.5%). Endomyocardial and pericardial aspergillosis are devastating complications of invasive aspergillosis. Clinical suspicion is low making the diagnosis difficult, therefore histopathological examination of tissues are required. The mortality is high.<\/jats:p>","DOI":"10.1111\/myc.12630","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T08:12:40Z","timestamp":1494576760000},"page":"576-580","source":"Crossref","is-referenced-by-count":7,"title":["Endomyocardial and pericardial aspergillosis in critically ill patients"],"prefix":"10.1111","volume":"60","author":[{"given":"George","family":"Dimopoulos","sequence":"first","affiliation":[{"name":"Department of Critical Care Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3897-6282","authenticated-orcid":false,"given":"Frantzeska","family":"Frantzeskaki","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinos","family":"Kosmopoulos","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio Sylvio","family":"Taccone","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Erasme Hospital Universit\u00e9 Libre de Bruxelles  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Marie","family":"Van den Abeele","sequence":"additional","affiliation":[{"name":"Department of Microbiology General Hospital St. Lucas  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Bulpa","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Mont\u2010Godinne University Hospital CHU UcL Namur Universit\u00e9 Catholique de Louvain  Yvoir Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"For\u00eat","sequence":"additional","affiliation":[{"name":"Intensive Care Department CHR \u2010 Mons\u2013Warquignies  Mons Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Vogelaers","sequence":"additional","affiliation":[{"name":"Deparment of Internal Medicine Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stijn","family":"Blot","sequence":"additional","affiliation":[{"name":"Deparment of Internal Medicine Ghent University  Ghent Belgium"},{"name":"Burns Trauma and Critical Care Research Centre The University of Queensland  Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"AspICU investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"21","article-title":"Invasive pulmonary aspergillosis: a study of 39 cases at autopsy","volume":"50","author":"Vaideeswar P","year":"2004","journal-title":"J Postgrad Med"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201111-1978OC"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2004.037"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc3488"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2003.15.1.71"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2011.614307"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-002-0599-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5858\/2008-132-606-TPOPDD"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.08.005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/516326"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/525258"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2012.690108"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0791-z"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2016.09.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"issue":"1","key":"e_1_2_6_17_1","first-page":"231","article-title":"Pulmonary aspergillosis: pathologic and pathogenetic features","volume":"28","author":"Fraser RS","year":"1993","journal-title":"Pathol Annu"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/323335"},{"key":"e_1_2_6_19_1","first-page":"1396","article-title":"Fungal sepsis in the ICU: are we doing better? 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