{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T21:34:48Z","timestamp":1773956088475,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Fusarium<\/jats:italic> species have emerged as an important human pathogen in skin disease, onychomycosis, keratitis and invasive disease. Onychomycosis caused by <jats:italic>Fusarium<\/jats:italic> spp. The infection has been increasingly described in the immunocompetent and immunosuppressed hosts. Considering onychomycosis is a difficult to treat infection, and little is known about the genetic variability and susceptibility pattern of <jats:italic>Fusarium<\/jats:italic> spp., further studies are necessary to understand the pathogenesis and better to define the appropriate antifungal treatment for this infection. Accordingly, the objective of this study was to describe the in vitro susceptibility to different antifungal agents and the genetic diversity of 35 <jats:italic>Fusarium<\/jats:italic> isolated from patients with onychomycosis. <jats:italic>Fusarium<\/jats:italic> spp. were isolated predominantly from female Caucasians, and the most frequent anatomical location was the nail of the hallux. Results revealed that 25 (71.4%) of isolates belonged to the <jats:italic>Fusarium solani<\/jats:italic> species complex, followed by 10 (28.5%) isolates from the <jats:italic>Fusarium oxysporum<\/jats:italic> species complex. Noteworthy, the authors report the first case of <jats:italic>Neocosmospora rubicola<\/jats:italic> isolated from a patient with onychomycosis. Amphotericin B was the most effective antifungal agent against the majority of isolates (60%, <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> \u22644\u00a0\u03bcg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>), followed by voriconazole (34.2%, <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> \u22644\u00a0\u03bcg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>). In general, <jats:italic>Fusarium<\/jats:italic> species presented <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> values &gt;64\u00a0\u03bcg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> for fluconazole, itraconazole and terbinafine. Accurate pathogen identification, characterisation and susceptibility testing provide a better understanding of pathogenesis of <jats:italic>Fusarium<\/jats:italic> in onychomycosis.<\/jats:p>","DOI":"10.1111\/myc.12638","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T11:49:05Z","timestamp":1498650545000},"page":"616-622","source":"Crossref","is-referenced-by-count":29,"title":["Genetic diversity and antifungal susceptibility of <i>Fusarium<\/i> isolates in onychomycosis"],"prefix":"10.1111","volume":"60","author":[{"given":"Priscila D.","family":"Rosa","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Medicina: Ci\u00eancias M\u00e9dicas Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiane","family":"Heidrich","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Medicina: 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