{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:04:47Z","timestamp":1761948287797,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Pneumocystis jirovecii<\/jats:italic> is the causative agent of <jats:italic>Pneumocystis<\/jats:italic> pneumonia (PcP), a common and often life\u2010threatening opportunistic infection in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients. However, non\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>, immunocompromised patients are at risk of PcP as well, whereas the mortality appears to be higher among these patients. <jats:italic>Pneumocystis<\/jats:italic> co\u2010infections with other microorganisms are less frequent and only sparse reports of combined PcP and invasive pulmonary fungal infections exist in the literature, especially in the non\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients. Two cases of pulmonary co\u2010infections by <jats:italic>P.\u00a0jirovecii<\/jats:italic> and <jats:italic>Aspergillus fumigatus<\/jats:italic> are presented. Both patients were non\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infected, the first one was suffering from crescentic IgA nephropathy under immunosuppressive treatment and the second from resistant non\u2010Hodgkin lymphoma under chemotherapy. Both patients were treated with intravenous trimethoprim\/sulphamethoxazole (<jats:styled-content style=\"fixed-case\">TMP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SMX<\/jats:styled-content>) combined with voriconazole. The first patient showed gradual clinical improvement while the outcome for the second patient was unfavourable. In addition, a literature review of the previous published cases of co\u2010infection by <jats:italic>P.\u00a0jirovecii<\/jats:italic> and other fungi in non\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients was performed. Our target was to provide comprehensive information on this kind of infections, highlighting the importance of clinical suspicion.<\/jats:p>","DOI":"10.1111\/myc.12642","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T02:37:04Z","timestamp":1498703824000},"page":"626-633","source":"Crossref","is-referenced-by-count":20,"title":["Pulmonary co\u2010infections by <i>Pneumocystis jirovecii<\/i> and <i>Aspergillus fumigatus<\/i> in non\u2010<scp>HIV<\/scp> patients: A report of two cases and literature review"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9024-9982","authenticated-orcid":false,"given":"Anthi\u2010Marina","family":"Markantonatou","sequence":"first","affiliation":[{"name":"First Department of Microbiology Medical School Aristotle University of Thessaloniki  Thessaloniki 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