{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:30:55Z","timestamp":1787679055399,"version":"build-2784847793"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,7,23]],"date-time":"2017-07-23T00:00:00Z","timestamp":1500768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Cryptococcus gattii<\/jats:italic> species complex has evolved as a pathogen in the last two decades causing infection among both immunocompetent and immunocompromised hosts. We aimed to analyse the clinical features of <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> infection caused by <jats:italic>C.\u00a0gattii sensu lato<\/jats:italic>, molecular and antifungal susceptibility profile of this pathogen. Cases diagnosed to have <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> cryptococcosis were included in the study. <jats:italic>Cryptococcus<\/jats:italic> recovered from patient's specimen was identified by standard protocol. Species confirmation, mating type and molecular type determination were performed by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> based methods. Antifungal susceptibility was tested in <jats:styled-content style=\"fixed-case\">VITEK<\/jats:styled-content>2C to amphotericin B, 5\u2010flucytosine, fluconazole and voriconazole. Among 199 cases, 20 (10%) were due to <jats:italic>C.\u00a0gattii<\/jats:italic>, comprising of 75% cryptococcal meningitis and 25% cryptococcoma cases. Young adult males were commonly affected. Headache and vomiting were prominent symptoms and 50% were immunocompromised. Among the isolates, 75%, 20% and 5% were <jats:italic>C.\u00a0tetragattii, C.\u00a0gattii sensu stricto<\/jats:italic> and <jats:italic>C.\u00a0bacillisporus<\/jats:italic> respectively and all had mating type \u03b1. Four (20%) isolates of <jats:italic>C.\u00a0tetragattii<\/jats:italic> and the only isolate of <jats:italic>C.\u00a0bacillisporus<\/jats:italic> were resistant to fluconazole. The most common species isolated from south India is <jats:italic>C.\u00a0tetragattii<\/jats:italic>. The study contributes to the epidemiology of <jats:italic>C.\u00a0gattii<\/jats:italic> and reiterates the need for genotyping and antifungal susceptibility testing.<\/jats:p>","DOI":"10.1111\/myc.12656","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T04:36:43Z","timestamp":1500871003000},"page":"749-757","source":"Crossref","is-referenced-by-count":14,"title":["Central nervous system infection due to <i>Cryptococcus gattii sensu lato<\/i> in India: Analysis of clinical features, molecular profile and antifungal susceptibility"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6918-2269","authenticated-orcid":false,"given":"Shayanki","family":"Lahiri Mukhopadhyay","sequence":"first","affiliation":[{"name":"Department of Neuromicrobiology National Institute of Mental Health and Neuro Sciences  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veenakumari H.","family":"Bahubali","sequence":"additional","affiliation":[{"name":"Department of Neuromicrobiology National Institute of Mental Health and Neuro Sciences  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Netravathi","family":"Manjunath","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neuro Sciences  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarthi","family":"Swaminathan","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging and Interventional Radiology National Institute of Mental Health and Neuro Sciences  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayani","family":"Maji","sequence":"additional","affiliation":[{"name":"Department of Neuromicrobiology National Institute of Mental Health and Neuro Sciences  Bangalore 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