{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:46:20Z","timestamp":1792118780805,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004061","name":"Oesterreichische Nationalbank","doi-asserted-by":"publisher","award":["15346"],"award-info":[{"award-number":["15346"]}],"id":[{"id":"10.13039\/501100004061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003413","name":"Bundesministerium f\u00fcr Wissenschaft, Forschung und Wirtschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007945","name":"Steirische Wirtschaftsf\u00f6rderungsgesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Summary<\/jats:title>Aspergillus<\/jats:italic> spp. have been shown to induce T\u2010helper cell (Th) 1 and Th17 subsets resulting in elevated levels of several cytokines. The objective of this study was to analyse a bundle of cytokines in serum and bronchoalveolar lavage fluid (BALF<\/jats:styled-content>) in patients with and without invasive pulmonary aspergillosis (IPA<\/jats:styled-content>). This nested case\u2010control analysis included 10 patients with probable\/proven IPA<\/jats:styled-content> and 20 matched controls without evidence of IPA<\/jats:styled-content>, out of a pool of prospectively enrolled (2014\u20102017) adult cases with underlying haematological malignancies and suspected pulmonary infection. Serum samples were collected within 24\u00a0hours of BALF<\/jats:styled-content> sampling. All samples were stored at \u221270\u00b0C for retrospective determination of cytokines. IL<\/jats:styled-content>\u20106 and IL<\/jats:styled-content>\u20108 were significantly associated with IPA<\/jats:styled-content> in both serum (P<\/jats:italic>\u00a0=\u00a0.011 and P<\/jats:italic>\u00a0=\u00a0.028) and BALF<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a0.006 and P<\/jats:italic>\u00a0=\u00a0.012, respectively), and a trend was observed for serum IL<\/jats:styled-content>\u201010 (P<\/jats:italic>\u00a0=\u00a0.059). In multivariate conditional logistic regression analysis, IL<\/jats:styled-content>\u201010 remained a significant predictor of IPA<\/jats:styled-content> in serum and IL<\/jats:styled-content>\u20108 among BALF<\/jats:styled-content> cytokines. In conclusion, levels of IL<\/jats:styled-content>\u20106 and IL<\/jats:styled-content>\u20108 were significantly associated with probable\/proven IPA<\/jats:styled-content>, and a similar trend was observed for serum IL<\/jats:styled-content>\u201010. Future cohort studies should determine the diagnostic potential of these cytokines for IPA<\/jats:styled-content>, and evaluate combinations with other IPA<\/jats:styled-content> biomarkers\/diagnostic tests.<\/jats:p>","DOI":"10.1111\/myc.12679","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T16:58:41Z","timestamp":1504717121000},"page":"818-825","source":"Crossref","is-referenced-by-count":47,"title":["Levels of interleukin (IL<\/scp>)\u20106 and IL<\/scp>\u20108 are elevated in serum and bronchoalveolar lavage fluid of haematological patients with invasive pulmonary aspergillosis"],"prefix":"10.1111","volume":"60","author":[{"given":"Sven","family":"Heldt","sequence":"first","affiliation":[{"name":"Division of Pulmonology Medical University of Graz Graz Austria"},{"name":"Section of Infectious Diseases and Tropical Medicine Medical University of Graz Graz 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