{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:25:25Z","timestamp":1740126325445,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>\n<jats:bold>Summary<\/jats:bold>\n<\/jats:title><jats:p>Duration &gt;120\u00a0minutes of extracorporeal circulation (<jats:styled-content style=\"fixed-case\">ECC<\/jats:styled-content>) during cardiopulmonary bypass procedure was associated to an increased risk of candidemia in the intensive care unit (<jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>). To evaluate oral nystatin prophylaxis in cardiac surgery considering its exclusive effect on <jats:italic>Candida<\/jats:italic>, in the absence of systemic effects and selection of resistant strains to polyene. We conducted an observational study in the postcardiac surgery <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> of Policlinico \u201cUmberto I\u201d of Rome. From January 2014, all patients with a prolonged <jats:styled-content style=\"fixed-case\">ECC<\/jats:styled-content> &gt;120\u00a0minutes were systematically treated with oral nystatin (Prophylaxis group). This group was compared with all patients hospitalised in the same <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>, who have not received oral nystatin after <jats:styled-content style=\"fixed-case\">ECC<\/jats:styled-content> &gt;120\u00a0minutes (No prophylaxis group). Overall, 672 consecutive patients were analyzed: 318 (47.3%) patients belonged to the no prophylaxis group, and 354 (52.7%) patients to the prophylaxis group. Diagnosis of candidemia was confirmed in 7 (2.2%) patients, all belonged to the no prophylaxis group. At multivariate analysis, oral nystatin prophylaxis showed a protective effect for development of candidemia after cardiac surgery. Oral nystatin prophylaxis, in patients who underwent a <jats:styled-content style=\"fixed-case\">ECC<\/jats:styled-content> &gt;120\u00a0minutes, seems to reduce development of candidemia; however, the real efficacy of such prophylaxis approach requires further investigation.<\/jats:p>","DOI":"10.1111\/myc.12680","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T16:57:05Z","timestamp":1504717025000},"page":"826-829","source":"Crossref","is-referenced-by-count":4,"title":["Role of oral nystatin prophylaxis in cardiac surgery with prolongedextracorporeal circulation"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3846-4620","authenticated-orcid":false,"given":"Alessandro","family":"Russo","sequence":"first","affiliation":[{"name":"Department of Public Health and Infectious Diseases \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Carriero","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7104-5826","authenticated-orcid":false,"given":"Alessio","family":"Farcomeni","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5921-3180","authenticated-orcid":false,"given":"Giancarlo","family":"Ceccarelli","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0480-1705","authenticated-orcid":false,"given":"Luigi","family":"Tritapepe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2639-0281","authenticated-orcid":false,"given":"Mario","family":"Venditti","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc7964"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024198"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.6.2244"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12470"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.257931"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/323759"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11300"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2807-x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/319763"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000181726.32675.37"},{"key":"e_1_2_6_12_1","first-page":"CD003478","article-title":"Prophylactic 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