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This study characterised 79 bloodstream isolates of<jats:italic>C. albicans<\/jats:italic>,<jats:italic>C. glabrata<\/jats:italic>,<jats:italic>C. orthopsilosis<\/jats:italic>,<jats:italic>C. parapsilosis<\/jats:italic>and<jats:italic>C. tropicalis<\/jats:italic>from patients in a Brazilian hospital. The susceptibility to amphotericin B, caspofungin, fluconazole and voriconazole was determined; virulence factor production was assessed based on haemolysin, phospholipase and proteinase activities, and the patients\u2019 clinical characteristics were analysed.<jats:italic>C. albicans<\/jats:italic>was the predominant species (44%), followed by<jats:italic>C. glabrata<\/jats:italic>(19%),<jats:italic>C. tropicalis<\/jats:italic>(19%),<jats:italic>C. parapsilosis<\/jats:italic>(14%) and<jats:italic>C. orthopsilosis<\/jats:italic>(4%). The candidemia incidence was 1.52 per 1000 admissions, and the crude mortality rate was 52%. One<jats:italic>C. albicans<\/jats:italic>isolate was resistant to fluconazole and voriconazole. Moreover, 20.2%, 2.5% and 3.8% of the isolates exhibited dose\u2010dependent susceptibility to fluconazole, voriconazole and caspofungin, respectively. In conclusion, although the<jats:italic>C. glabrata<\/jats:italic>incidence was higher than that usually described in Brazil, its increase was previously observed in studies conducted worldwide. Furthermore, the azole resistance of the<jats:italic>C. albicans<\/jats:italic>isolate could be due to previous exposure to these antifungals. These results highlight the importance of epidemiological studies and will facilitate an improved understanding of candidemia in the studied hospital.<\/jats:p>","DOI":"10.1111\/myc.12695","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T09:52:46Z","timestamp":1506073966000},"page":"11-21","source":"Crossref","is-referenced-by-count":62,"title":["Prevalence, virulence factors and antifungal susceptibility of<i>Candida<\/i>spp. isolated from bloodstream infections in a tertiary care hospital in Brazil"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-3777","authenticated-orcid":false,"given":"Heliara Maria Spina","family":"Canela","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto\u2014Universidade de S\u00e3o Paulo Ribeir\u00e3o Preto S\u00e3o Paulo 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