{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:42:55Z","timestamp":1778647375067,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004176","name":"Miltenyi Biotec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Invasive <jats:italic>Candida<\/jats:italic> infection is the fourth most common bloodstream infection. Blood cultures are the current gold standard diagnostic method, however, false negatives remain a clinical challenge. We developed a new technique measuring <jats:italic>Candida<\/jats:italic>\u2010reactive T cells as diagnostic read\u2010out for invasive <jats:italic>Candida<\/jats:italic> infection. In a pilot study, we followed the treatment course of a patient with an invasive <jats:italic>Candida<\/jats:italic> infection of the lumbar vertebral spine. We present the case of a 56\u2010year\u2010old patient with HIV\u2010associated Burkitt lymphoma who developed septic shock during chemotherapy\u2010induced neutropenia. For the first time, we provide flow cytometry\u2010based diagnostics with <jats:italic>Candida<\/jats:italic>\u2010reactive T\u00a0cells for invasive candidiasis with comprehensive MRI imaging. The <jats:italic>Candida<\/jats:italic>\u2010reactive T\u00a0cell assay has potential to complement current diagnostic assays for invasive <jats:italic>Candida<\/jats:italic> infection and thus to support targeted treatment.<\/jats:p>","DOI":"10.1111\/myc.12696","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T11:05:57Z","timestamp":1504609557000},"page":"48-52","source":"Crossref","is-referenced-by-count":9,"title":["<i>Candida<\/i>\u2010reactive T cells for the diagnosis of invasive <i>Candida<\/i> infection of the lumbar vertebral spine"],"prefix":"10.1111","volume":"61","author":[{"given":"Felix C.","family":"Koehler","sequence":"first","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-3137","authenticated-orcid":false,"given":"Oliver 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