{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:28:19Z","timestamp":1778722099686,"version":"3.51.4"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,15]],"date-time":"2017-10-15T00:00:00Z","timestamp":1508025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Tinea pedis and onychomycosis are among the commonest fungal diseases in the world. Dermatophytes and, less frequently, non\u2010dermatophyte moulds are aetiological agents of foot mycosis and are capable of forming biofilms. Fungal biofilm has demonstrated increasing drug resistance. This work aims to evaluate, in vitro, the ability to form biofilm and the susceptibility to antifungal drugs of sessile dermatophytes and non\u2010dermatophyte moulds involved in foot mycosis. Thirty\u2010six dermatophytes and non\u2010dermatophyte moulds isolated from Tunisian patients with foot mycoses, and identified with <jats:styled-content style=\"fixed-case\">MALDI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> have been tested. <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s of fluconazole, econazole, itraconazole, terbinafine and griseofulvin were carried out using <jats:styled-content style=\"fixed-case\">CLSI<\/jats:styled-content> broth microdilution method. The ability to form biofilm and antifungal activities of drugs against fungal biofilm formation has been quantified by Crystal Violet and Safranin Red staining. Biomass quantification revealed that all species studied were able to form biofilms in vitro after 72\u00a0hours. Fluconazole, econazole, itraconazole and terbinafine inhibited fungal growth with <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> values ranging from 0.031 to &gt;64\u00a0\u03bcg\u00a0mL<jats:sup>\u22121<\/jats:sup>. The best antifungal activity has been obtained with terbinafine against <jats:italic>Fusarium solani<\/jats:italic>. Econazole showed the highest activity against fungal biofilm formation. These findings can help clinicians to develop the appropriate therapy of foot mycosis.<\/jats:p>","DOI":"10.1111\/myc.12706","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T14:02:46Z","timestamp":1506088966000},"page":"79-87","source":"Crossref","is-referenced-by-count":26,"title":["In vitro biofilms and antifungal susceptibility of dermatophyte and non\u2010dermatophyte moulds involved in foot mycosis"],"prefix":"10.1111","volume":"61","author":[{"given":"Nourch\u00e9ne","family":"Toukabri","sequence":"first","affiliation":[{"name":"Laboratory of Mycology, Pathologies and Biomarkers Faculty of Sciences of Tunis University Tunis El Manar  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Corpologno","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases \u201cSapienza\u201d University of Rome  Rome 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