{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:11:18Z","timestamp":1777651878084,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["2206"],"award-info":[{"award-number":["2206"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Aspergillus terreus<\/jats:italic> infections are difficult to treat because of the intrinsic resistance to amphotericin B, and higher mortality compared to infections caused by other <jats:italic>Aspergillus<\/jats:italic> species. The aim of the present study was to determine the in vitro antifungal activity of amphotericin B and 11 comparators against clinical (n\u00a0=\u00a036) and environmental (n\u00a0=\u00a045) A.<jats:italic>\u00a0terreus<\/jats:italic> isolates. In vitro antifungal susceptibility was performed using the <jats:styled-content style=\"fixed-case\">CLSI<\/jats:styled-content> M38\u2010A2 procedure. Amphotericin B exhibited the highest <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> range, 0.125\u20104\u00a0\u03bcg\/mL; <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content><jats:sub>90<\/jats:sub>, 2\u00a0\u03bcg\/mL), followed by terbinafine (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> range, 0.002\u20101\u00a0\u03bcg\/mL; <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content><jats:sub>90<\/jats:sub>, 1\u00a0\u03bcg\/mL). Only one isolate (1\/81) showed amphotericin B <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> above the epidemiologic cut\u2010off value (<jats:styled-content style=\"fixed-case\">ECV<\/jats:styled-content>; 4\u00a0\u03bcg\/mL). None of the isolates had a <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> of \u2265 <jats:styled-content style=\"fixed-case\">ECV<\/jats:styled-content> for voriconazole, itraconazole and posaconazole. The reasons for the difference in amphotericin B susceptibility patterns between studies remain unknown. The genetic and species diversity, clinical, environmental and ecological factors in <jats:italic>Terrei<\/jats:italic> section on various amphotericin B susceptibility profiles in different countries should be considered more as the main reasons associated with these differences.<\/jats:p>","DOI":"10.1111\/myc.12716","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T11:38:36Z","timestamp":1508845116000},"page":"134-142","source":"Crossref","is-referenced-by-count":27,"title":["In vitro antifungal activity of amphotericin B and 11 comparators against <i>Aspergillus terreus<\/i> species complex"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8261-7386","authenticated-orcid":false,"given":"Afsane","family":"Vaezi","sequence":"first","affiliation":[{"name":"Department of Medical Mycology and Parasitology Invasive Fungi Research Center School of Medicine Mazandaran University of Medical Sciences  Sari 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Parasitology Invasive Fungi Research Center School of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad T.","family":"Hedayati","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology and Parasitology Invasive Fungi Research Center School of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadegh","family":"Khodavaisy","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology and Parasitology School of Public Health Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Rezaei\u2010Matehkolaei","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parisa","family":"Badiee","sequence":"additional","affiliation":[{"name":"Alborzi Clinical Microbiology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-1916","authenticated-orcid":false,"given":"Ferry","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases Canisius\u2010Wilhelmina Hospital (CWZ)  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Lass\u2010Fl\u00f6rl","sequence":"additional","affiliation":[{"name":"Division of Hygiene and Medical Microbiology Medical University of Innsbruck  Innsbruck 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