{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:12:18Z","timestamp":1777651938139,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["grant (nr. 1003)"],"award-info":[{"award-number":["grant (nr. 1003)"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Aspergillus fumigatus<\/jats:italic> is the leading cause of mortality in severely immunocompromised individuals. Understanding pathogen dispersion and relatedness is essential for determining the epidemiology of nosocomial infections. Therefore, the aim of this study was to investigate the diversity and putative origins of clinical and environmental azole\u2010susceptible and \u2010resistant <jats:italic>A.\u00a0fumigatus<\/jats:italic> isolates from Iran. In all, 79 isolates, including 64 azole\u2010susceptible and 15 \u2010resistant isolates, were genotyped using the cell surface protein (<jats:styled-content style=\"fixed-case\">CSP<\/jats:styled-content>) gene. Seven distinct repeat types (r01, r02, r03, r04, r05, r06 and r07) and 11 different <jats:styled-content style=\"fixed-case\">CSP<\/jats:styled-content> variants (t01, t02, t03, t04A, t06A, t06B, t08, t10, t18A, t18B and t22) were observed. Interestingly, t06B, t18A and t18B were exclusively present in azole\u2010resistant isolates. The Simpson's index of diversity (D) was calculated at 0.78. Resistant isolates were genetically less diverse than azole\u2010susceptible isolates. However, azole\u2010resistant <jats:italic>A.\u00a0fumigatus<\/jats:italic> without <jats:styled-content style=\"fixed-case\">TR<\/jats:styled-content><jats:sub>34<\/jats:sub>\/L98H were more diverse than with <jats:styled-content style=\"fixed-case\">TR<\/jats:styled-content><jats:sub>34<\/jats:sub>\/L98H. The limited <jats:styled-content style=\"fixed-case\">CSP<\/jats:styled-content> type diversity of the <jats:styled-content style=\"fixed-case\">TR<\/jats:styled-content><jats:sub>34<\/jats:sub>\/L98H isolates versus azole\u2010susceptible isolates suggests that repeated independent emergence of the <jats:styled-content style=\"fixed-case\">TR<\/jats:styled-content><jats:sub>34<\/jats:sub>\/L98H mechanism is unlikely. It has been suggested that <jats:styled-content style=\"fixed-case\">CSP<\/jats:styled-content> types might have a common ancestor that developed locally and subsequently migrated worldwide.<\/jats:p>","DOI":"10.1111\/myc.12717","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T11:56:47Z","timestamp":1508846207000},"page":"143-147","source":"Crossref","is-referenced-by-count":9,"title":["Use of cell surface protein typing for genotyping of azole\u2010resistant and \u2010susceptible <i>Aspergillus fumigatus<\/i> isolates in Iran"],"prefix":"10.1111","volume":"61","author":[{"given":"Mahsa","family":"Falahatinejad","sequence":"first","affiliation":[{"name":"Student Research Committee Mazandaran University of Medical Sciences  Sari 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