{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:25:27Z","timestamp":1740126327696,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Spanish Network for Research in Infectious Diseases","award":["REIPI RD 12\/0015"],"award-info":[{"award-number":["REIPI RD 12\/0015"]}]},{"name":"Fondo de Investigacion Sanitaria Sara Borrell Fellowship","award":["CD13\/00198"],"award-info":[{"award-number":["CD13\/00198"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["FIS: PI13\/02783"],"award-info":[{"award-number":["FIS: PI13\/02783"]}]},{"name":"Fondo de Investigacion Sanitaria","award":["FIS: PI15_00019"],"award-info":[{"award-number":["FIS: PI15_00019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A clear link between mating type and virulence has been demonstrated for some fungal pathogens, but not for <jats:italic>Aspergillus fumigatus<\/jats:italic> as of yet. An association between mating type and invasiveness has recently been established. The mating type proportion (<jats:styled-content style=\"fixed-case\">MAT<\/jats:styled-content>1\u20101:<jats:styled-content style=\"fixed-case\">MAT<\/jats:styled-content>1\u20102) of 213 <jats:italic>A.\u00a0fumigatus<\/jats:italic> strains was determined (48.5%:51.5%) and results were in agreement with previous studies. However, these percentages changed when the strain collection was divided into azole\u2010susceptible and \u2010resistant strains. The 163 susceptible strains kept these proportions, but among the 50 azole\u2010resistant strains 60.0% <jats:styled-content style=\"fixed-case\">MAT<\/jats:styled-content>1\u20101 and 40% <jats:styled-content style=\"fixed-case\">MAT<\/jats:styled-content>1\u20102 were found. Moreover, looking at the clinical outcome associated to 27 azole\u2010resistant strains, we found that <jats:styled-content style=\"fixed-case\">MAT<\/jats:styled-content>1\u20101 was linked to a high mortality rate (64%), whereas the rate associated to <jats:styled-content style=\"fixed-case\">MAT<\/jats:styled-content>1\u20102 genotype was markedly lower (15%). The pathogenicity linked to the Mat type was tested in a <jats:italic>Galleria mellonella<\/jats:italic> model of infection, showing that <jats:styled-content style=\"fixed-case\">MAT<\/jats:styled-content>1\u20101 strains were consistently more pathogenic than <jats:styled-content style=\"fixed-case\">MAT<\/jats:styled-content>1\u20102, independently of their susceptibility phenotype. This data would suggest that <jats:italic>A.\u00a0fumigatus<\/jats:italic> mating type determination at the time of diagnosis could have a prognostic value in invasive aspergillosis.<\/jats:p>","DOI":"10.1111\/myc.12720","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T06:46:39Z","timestamp":1509345999000},"page":"172-178","source":"Crossref","is-referenced-by-count":5,"title":["Could the determination of <i>Aspergillus fumigatus<\/i> mating type have prognostic value in invasive aspergillosis?"],"prefix":"10.1111","volume":"61","author":[{"given":"Maria Candida","family":"Monteiro","sequence":"first","affiliation":[{"name":"Mycology Reference Laboratory Centro Nacional de Microbiologia Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocio","family":"Garcia\u2010Rubio","sequence":"additional","affiliation":[{"name":"Mycology Reference Laboratory Centro Nacional de Microbiologia Instituto 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