{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:35:48Z","timestamp":1776861348786,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","award":["26990"],"award-info":[{"award-number":["26990"]}],"id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Summary<\/jats:title>Recurrent vulvovaginal candidiasis (RVVC<\/jats:styled-content>) is a common opportunistic, mucosal fungal infection, predominantly caused by the fungus Candida albicans<\/jats:italic>. Mannose\u2010binding lectin (MBL<\/jats:styled-content>) is an acute\u2010phase protein that plays a key role in the innate immunity defence against infectious disease. This study was conducted to evaluate the relationship between the MBL<\/jats:styled-content> serum level and the relative expression of MBL<\/jats:styled-content><\/jats:italic> mRNA<\/jats:styled-content> in RVVC<\/jats:styled-content> using real\u2010time PCR<\/jats:styled-content> for the first time. The case\u2010control study included 40 female participants suffering from RVVC<\/jats:styled-content> and 40 healthy individuals. The MBL<\/jats:styled-content> serum level was measured using a commercial ELISA<\/jats:styled-content> kit. The relative mRNA<\/jats:styled-content> expression of the MBL<\/jats:styled-content><\/jats:italic> gene was quantified using real\u2010time PCR<\/jats:styled-content>. Data analysis was carried out by spss<\/jats:sc> software. The MBL<\/jats:styled-content> concentration was significantly higher in the participants suffering from RVVC<\/jats:styled-content> compared to the control group (0.330\u00a0ng\/mL vs 0.253\u00a0ng\/mL). The prognostic value (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001) for RVVC<\/jats:styled-content> diagnosis has been calculated. Quantitative RT<\/jats:styled-content>\u2010PCR<\/jats:styled-content> results from 35 samples showed a low to significant values for mRNA<\/jats:styled-content> levels corresponding to MBL<\/jats:styled-content><\/jats:italic> gene expression (1\u2010352 folds) (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001). The results of this study suggest that MBL<\/jats:styled-content> plays a main role in the innate immunity and it is also affected by environmental factors and other genetic variations. Therefore, the MBL<\/jats:styled-content><\/jats:italic> gene expression profile does not reflect precise phenotypic levels in the serum.<\/jats:p>","DOI":"10.1111\/myc.12723","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T02:12:41Z","timestamp":1510020761000},"page":"106-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Is mannose\u2010binding lectin serum concentration a reliable predictor for recurrent vulvovaginal candidiasis?"],"prefix":"10.1111","volume":"62","author":[{"given":"Mona","family":"Ghazanfari","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology and Mycology School of Medicine Iran University of Medical Sciences Tehran 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Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Khoshmirsafa","sequence":"additional","affiliation":[{"name":"Department of Immunology Faculty of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Farzanegan","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Mycology School of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-002-0038-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.9.3.335"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033114"},{"key":"e_1_2_7_5_1","unstructured":"MillerM.Recurrent vulvovaginitis: tips for treating a common condition 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