{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:46:33Z","timestamp":1771512393849,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Posaconazole is an extended\u2010spectrum triazole antifungal used in the treatment and prophylaxis of <jats:italic>Aspergillus<\/jats:italic> infections. It is available as oral suspension (POS\u2010Liq) and delayed\u2010release tablets (POS\u2010Tab). The aim of this longitudinal, retrospective study was to compare the clinical effectiveness, toxicity and pharmacokinetics of POS\u2010Liq vs POS\u2010Tab in lung transplant recipients (LTx\u2010recipients), who were treated with both formulations subsequently. Twenty\u2010four consecutive LTx\u2010recipients with 191 documented posaconazole trough levels (PTLs) for POS\u2010Liq or POS\u2010Tab were included. The administered daily doses were 300\u00a0mg for POS\u2010Tab and 600\u00a0mg (prophylaxis) or 800\u00a0mg (therapy) for POS\u2010Liq. Target PTLs were \u2265700\u00a0ng\/mL (prophylaxis) and \u22651250\u00a0ng\/mL (therapy). The overall prophylactic and therapeutic response rates were 78% and 67%, respectively. No cases of hepatotoxicity or QT\u2010prolongation were observed with either formulation. The achieved target PTLs were tripled under POS\u2010Tab compared to POS\u2010Liq with fewer risk factors for sub\u2010therapeutic PTLs. Concomitant administration of POS\u2010Tab significantly reduced the tacrolimus concentration\u2010to\u2010dose ratio (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.001). We suggest the use of POS\u2010Tab is appropriate for prophylaxis and therapy of <jats:italic>Aspergillus<\/jats:italic> infections in LTx\u2010recipients, since POS\u2010Tab displayed more reliable PTLs with no added adverse events. However, we recommend regular drug monitoring for POS\u2010Liq and for therapy with POS\u2010Tab and that immunosuppressant levels are monitored closely when the posaconazole formulation is switched.<\/jats:p>","DOI":"10.1111\/myc.12724","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T02:12:42Z","timestamp":1510020762000},"page":"186-194","source":"Crossref","is-referenced-by-count":26,"title":["Posaconazole liquid vs tablet formulation in lung transplant recipients"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2063-5532","authenticated-orcid":false,"given":"D.","family":"Stelzer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine V LMU\u2010Munich  Munich Germany"},{"name":"Comprehensive Pneumology Center Member of the German Center for Lung Research DZL  Munich Germany"},{"name":"Hospital Pharmacy LMU\u2010Munich  Munich 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