{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:55:17Z","timestamp":1771340117212,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Fungal sensitisation in adults is associated with severe asthma but prevalence and clinical significance of fungal sensitisation remains unclear in paediatric population. The aim of this study was to study the association of fungal sensitisation with disease severity in children with persistent asthma. One hundred children with persistent asthma in age group 7\u201015\u00a0years, symptom duration &gt;2\u00a0years and forced expiratory volume in first second &gt;50% of expected were enrolled. Skin prick test (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) to 8 fungal antigens and total serum immunoglobulin E (IgE) were done. Fungal sensitisation was described as positive <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> (wheel diameter more than 3\u00a0mm larger than the negative control) to any of the fungal antigens and total serum IgE &gt;200\u00a0ng\/mL. Seventeen patients showed evidence of fungal sensitisation, of which, 6 demonstrated sensitisation to multiple fungi. 17.6% patients with fungal sensitisation had severe asthma as compared to 2.4% patients without fungal sensitisation (<jats:italic>P<\/jats:italic> value .032). Significant increase in family history of allergic comorbidities was noted among patients with fungal sensitisation (47.1% vs 21.7%, <jats:italic>P<\/jats:italic> value .03). The most common implicated organism in fungal sensitised patients was <jats:italic>Aspergillus flavus<\/jats:italic> (47.1%). The results of this study, a first among Indian children with asthma, suggest that children with fungal sensitisation have more severe asthma as compared to children without fungal sensitisation.<\/jats:p>","DOI":"10.1111\/myc.12726","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T02:16:34Z","timestamp":1510020994000},"page":"195-200","source":"Crossref","is-referenced-by-count":16,"title":["Correlation between fungal sensitisation in childhood persistent asthma and disease severity"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5897-7912","authenticated-orcid":false,"given":"Aman","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Pediatrics Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenu","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-3807","authenticated-orcid":false,"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph L.","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Pocket Guide for Asthma Management and Prevention (Internet). 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