{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:45:01Z","timestamp":1791402301335,"version":"4.3.3"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    This is an observational\u2010retrospective study comparing the real\u2010world outcomes associated with posaconazole vs itraconazole as prophylaxis treatments. Two hundred and ninety\u2010three patient admissions attributable to 174 patients were included in the study. Patients were treated with itraconazole (n\u00a0=\u00a0114 admissions; 39%) or posaconazole (n\u00a0=\u00a0179; 61%). Antifungal prophylaxis failure (\n                    <jats:styled-content style=\"fixed-case\">APF<\/jats:styled-content>\n                    ) due to treatment\u2010related adverse events (in 34 out of 293 patient admissions; 11.6%) was more frequent in the posaconazole group (6.1% vs 15.1%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.024). There were 9 patient admissions for episodes of\n                    <jats:styled-content style=\"fixed-case\">APF<\/jats:styled-content>\n                    due to probable\/proven breakthrough fungal infection (primary endpoint): 6 and 3 in the itraconazole and posaconazole group respectively (5.3% vs 1.7%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.095). All of them were associated with invasive pulmonary aspergillosis (\n                    <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>\n                    ).\n                    <jats:styled-content style=\"fixed-case\">APF<\/jats:styled-content>\n                    was more frequent with itraconazole (65% vs 30%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001), along with failure due to possible\/probable\/proven\n                    <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>\n                    (25% vs 10%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.002) and overall failure by any of the 3 different causes of prophylaxis failure (70% vs 38%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001). In agreement with clinical trial data, this real\u2010world evidence supports the use of posaconazole over itraconazole in\n                    <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\n                    or\n                    <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>\n                    patients undergoing intensive chemotherapy.\n                  <\/jats:p>","DOI":"10.1111\/myc.12728","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T11:22:40Z","timestamp":1510312960000},"page":"206-212","source":"Crossref","is-referenced-by-count":21,"title":["Primary prophylaxis of invasive fungal infections with posaconazole or itraconazole in patients with acute myeloid leukaemia or high\u2010risk myelodysplastic syndromes undergoing intensive cytotoxic chemotherapy: A real\u2010world comparison"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9622-1649","authenticated-orcid":false,"given":"Mar","family":"Tormo","sequence":"first","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario\u2010INCLIVA  Valencia Spain"},{"name":"Department of Medicine University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna","family":"P\u00e9rez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3250-820X","authenticated-orcid":false,"given":"Marisa","family":"Calabuig","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4289-3113","authenticated-orcid":false,"given":"Juan Carlos","family":"Hern\u00e1ndez\u2010Boluda","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6321-4952","authenticated-orcid":false,"given":"Paula","family":"Amat","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-4110","authenticated-orcid":false,"given":"David","family":"Navarro","sequence":"additional","affiliation":[{"name":"Microbiology Service Hospital Cl\u00ednico Universitario\u2010INCLIVA  Valencia Spain"},{"name":"Department of Microbiology University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3702-0817","authenticated-orcid":false,"given":"Carlos","family":"Solano","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario\u2010INCLIVA  Valencia Spain"},{"name":"Department of Medicine University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.374"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.012054"},{"key":"e_1_2_7_4_1","first-page":"351","article-title":"Empiric antifungal therapy for the neutropenic patient","volume":"15","author":"Wingard JR","year":"2001","journal-title":"Oncology (Williston Park)"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-009-9188-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12060"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70238-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2108-y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir073"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.175"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.3851"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.147"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2644"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05727.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061094"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.3.4.467"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2165\/00024669-200504040-00007","article-title":"Pegfilgrastim: a review of its use in chemotherapy\u2010induced neutropenia","volume":"4","author":"Frampton JE","year":"2005","journal-title":"Am J Cancer"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis773"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26273"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0093"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.8661"},{"key":"e_1_2_7_23_1","first-page":"986","article-title":"Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15\u2010year period (1989\u20132003)","volume":"91","author":"Chamilos G","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0855-6"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.051995"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.185"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq121"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2010.01979.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2010.01980.x"},{"key":"e_1_2_7_30_1","first-page":"681","article-title":"Risk factors for invasive aspergillosis in acute myeloid leukemia patients prophylactically treated with posaconazole","volume":"49","author":"Michallet M","year":"2011","journal-title":"Med Mycol"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23388"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2011.090464"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T11:19:06Z","timestamp":1695640746000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/myc.12728"],"URL":"https:\/\/doi.org\/10.1111\/myc.12728","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732100116.793539471","asserted-by":"object"}]},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,3]]}}}