{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:02:30Z","timestamp":1792245750651,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Isavuconazole is a novel antifungal drug approved for the treatment of adults with invasive aspergillosis and mucormycosis. While azoles as a class effect are known to prolong <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval, clinical trials have shown that isavuconazole administration may cause shortening in a dose\u2010related manner. Here, we assessed the effects of isavuconazole on the length of <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval. The objective of the study was to describe changes in the <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval induced by isavuconazole treatment. A total of 26 adult patients from 7 hospitals were included. Patients received isavuconazole for the treatment of invasive fungal infection and, in 1 case, for prophylaxis due to <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c prolongation under fluconazole. Twelve\u2010channel electrocardiograms (ECGs) were performed before and during treatment. Out of 26 patients, 24 showed shortening of <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval. In patients with <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c shortening, <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c during isavuconazole treatment showed a mean decrease of 7.4\u00a0\u00b1\u00a05.8% (36.5\u00a0\u00b1\u00a038.8\u00a0ms, range 7\u2010202; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004), compared to pre\u2010isavuconazole ECG. One patient with available long\u2010term follow\u2010up showed further decrease in <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c on days 55 and 110. Apart from 1 case report, these are the first data outside controlled clinical trials showing <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c shortening. Knowledge about cardiac effects of isavuconazole will serve to better manage the use of concomitant medications.<\/jats:p>","DOI":"10.1111\/myc.12731","type":"journal-article","created":{"date-parts":[[2017,11,25]],"date-time":"2017-11-25T15:46:46Z","timestamp":1511624806000},"page":"256-260","source":"Crossref","is-referenced-by-count":58,"title":["Isavuconazole shortens the QTc interval"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3928-2503","authenticated-orcid":false,"given":"Sibylle C.","family":"Mellinghoff","sequence":"first","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) University of Cologne  Cologne Germany"},{"name":"Department I of Internal Medicine German Centre for Infection Research (DZIF) University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bassetti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division Santa Maria Misericordia University Hospital  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"D\u00f6rfel","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology , Hematology, Immunology, Rheumatology and Pulmology University Hospital T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Clinical Collaboration Unit Translational Immunology German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Partner site T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-6131","authenticated-orcid":false,"given":"Stefan","family":"Hagel","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Infection Control Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-2564","authenticated-orcid":false,"given":"Nicola","family":"Lehners","sequence":"additional","affiliation":[{"name":"Department V of Internal Medicine University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Plis","sequence":"additional","affiliation":[{"name":"Department of Haematology, Oncology Palliative Medicine and Transplantation Centre University Hospital in Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1892-5098","authenticated-orcid":false,"given":"Enrico","family":"Schalk","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology Medical Centre Otto\u2010von\u2010Guericke University Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0697-3992","authenticated-orcid":false,"given":"Antonio","family":"Vena","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division Santa Maria Misericordia University Hospital  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-3137","authenticated-orcid":false,"given":"Oliver A.","family":"Cornely","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) University of Cologne  Cologne Germany"},{"name":"Department I of Internal Medicine German Centre for Infection Research (DZIF) University of Cologne  Cologne Germany"},{"name":"Clinical Trials Centre Cologne (ZKS K\u00f6ln) University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-10-199911160-00034"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2014.03.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.896946"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.620"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01159-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.1997.tb00325.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv316"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02571.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051115"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2004.04.006"},{"key":"e_1_2_7_12_1","unstructured":"Astellas Pharma US & Inc.CRESEMBA\u00ae(isavuconazonium sulfate) prescribing information.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2015\/207500Orig1s000lbl.pdf. 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