{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:25:28Z","timestamp":1740126328369,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Paracoccidioidomycosis (<jats:styled-content style=\"fixed-case\">PCM<\/jats:styled-content>) is a systemic mycosis prevalent among immunocompetent patients in Latin America. This study aimed to describe the frequency, demographics and clinical characteristics of central nervous system <jats:styled-content style=\"fixed-case\">PCM<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">NPCM<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">PCM<\/jats:styled-content> in an endemic region, and the impact of human immunosuppression virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>) co\u2010infection. This was a retrospective study of autopsy and biopsy reports from the Medical Pathology Section of the Hospital de Clinicas, <jats:styled-content style=\"fixed-case\">UFPR<\/jats:styled-content>, Curitiba, Southern Brazil, between 1951 and 2014. <jats:styled-content style=\"fixed-case\">PCM<\/jats:styled-content> was present in 0.1% of 378,323 cases examined, with 5.7% being <jats:styled-content style=\"fixed-case\">NPCM<\/jats:styled-content>. Infection was prevalent in working\u2010age men, agricultural workers and rural residents. Numbers of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> autopsy cases increased over time, while those of <jats:styled-content style=\"fixed-case\">PCM<\/jats:styled-content> cases decreased. Prevalence of co\u2010infection of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PCM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NPCM<\/jats:styled-content> was 1.6%, and 0.4%, respectively. Adrenals were affected more frequently in the <jats:styled-content style=\"fixed-case\">NPCM<\/jats:styled-content> group compared with the <jats:styled-content style=\"fixed-case\">PCM<\/jats:styled-content> group. Mortality was higher on <jats:styled-content style=\"fixed-case\">NPCM<\/jats:styled-content> group. The clinical course of <jats:styled-content style=\"fixed-case\">PCM<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients resembles an acute\/sub\u2010acute infection. Association of <jats:styled-content style=\"fixed-case\">NPCM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> is rare, while diagnosis of <jats:styled-content style=\"fixed-case\">NPCM<\/jats:styled-content> is difficult, it should be considered a differential diagnosis in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients who live in, or have visited, endemic areas and present with neurological symptoms.<\/jats:p>","DOI":"10.1111\/myc.12737","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T10:19:43Z","timestamp":1514110783000},"page":"237-244","source":"Crossref","is-referenced-by-count":8,"title":["Autopsy and biopsy study of paracoccidioidomycosis and neuroparacoccidioidomycosis with and without <scp>HIV<\/scp> co\u2010infection"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5690-105X","authenticated-orcid":false,"given":"Sergio Monteiro","family":"de Almeida","sequence":"first","affiliation":[{"name":"Medical Patology Departament Medicine School Universidade Federal do Paran\u00e1  Curitiba Brazil"},{"name":"Virology Laboratory Hospital de Clinicas Universidade Federal do Paran\u00e1  Curitiba Brazil"},{"name":"Faculdades Pequeno Pr\u00edncipe  Curitiba Brazil"},{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Henrique","family":"Roza","sequence":"additional","affiliation":[{"name":"Medical Patology Departament Medicine School Universidade Federal do Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel L.O.","family":"Salvador","sequence":"additional","affiliation":[{"name":"Medical Patology Departament Medicine School Universidade Federal do Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds Felipe","family":"Izycki","sequence":"additional","affiliation":[{"name":"Medical Patology Departament Medicine School Universidade Federal do Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliana","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Medical Patology Departament Medicine School Universidade Federal do Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaias dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Medical Patology Departament Medicine School Universidade Federal do Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afonso","family":"Arag\u00e3o","sequence":"additional","affiliation":[{"name":"Medical Patology Departament Medicine School Universidade Federal do Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Fernando Bleggi","family":"Torres","sequence":"additional","affiliation":[{"name":"Medical Patology Departament Medicine School Universidade Federal do Paran\u00e1  Curitiba Brazil"},{"name":"Faculdades Pequeno Pr\u00edncipe  Curitiba Brazil"},{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Helena","family":"de Noronha","sequence":"additional","affiliation":[{"name":"Medical Patology Departament Medicine School Universidade Federal do Paran\u00e1  Curitiba Brazil"},{"name":"Laborat\u00f3rio de Patologia Experimental Escola de Medicina\u2010 Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,23]]},"reference":[{"volume-title":"Sustaining the drive to overcome the global impact of neglected tropical diseases: second WHO report on neglected tropical 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