{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:47:31Z","timestamp":1793321251271,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Scedosporium apiospermum<\/jats:italic> is a ubiquitous filamentous fungus, commonly found in soil, sewage and polluted waters. It is rarely pathogenic but can cause a broad spectrum of clinical diseases, which can be localised or disseminate to distant organs. The disseminated form of the disease is mostly seen among immunocompromised patients. However, some rare cases of disseminated disease have been reported in immunocompetent individuals. Treatment of these infections is challenging because of their natural resistance to many antifungal agents. Here, we report the case of a 57\u2010year\u2010old immunocompetent patient diagnosed with femoral pseudarthrosis due to <jats:italic>S.\u00a0apiospermum<\/jats:italic>, despite having no obvious clinical sign of infection. Previously, the patient had undergone four iterative femoral surgeries following a road traffic accident which occurred 20\u00a0years before. During its last surgery for pseudarthrosis, no clinical or biological signs of infection were present. Per operative samples tested positive for <jats:italic>S.\u00a0apiospermum<\/jats:italic>. The patient was successfully treated with oral voriconazole during 6\u00a0months with an excellent tolerance. We also provide a review of literature on bone and joint infections due to <jats:italic>Scedosporium<\/jats:italic> spp. (<jats:italic>S.\u00a0apiospermum<\/jats:italic>,<jats:italic> Scedosporium boydii<\/jats:italic> and <jats:italic>Scedosporium aurantiacum<\/jats:italic>), discussing the evolution of their management and outcome which seems to improve since the use of voriconazole.<\/jats:p>","DOI":"10.1111\/myc.12739","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T10:20:33Z","timestamp":1514110833000},"page":"400-409","source":"Crossref","is-referenced-by-count":9,"title":["Case of femoral pseudarthrosis due to <i>Scedosporium apiospermum<\/i> in an immunocompetent patient with successful conservative treatment and review of 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