{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:54Z","timestamp":1787015754939,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"routine patient evaluation and treatment"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>We describe a case of apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis and low plasma renin activity) secondary to itraconazole therapy. Inhibition of 11\u03b2\u2010hydroxysteroid dehydrogenase 2 was demonstrated, and withholding itraconazole led to resolution of adverse effects that did not recur with voriconazole. This report adds to a growing body of evidence linking apparent mineralocorticoid excess with certain triazoles.<\/jats:p>","DOI":"10.1111\/myc.12749","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T17:38:02Z","timestamp":1517420282000},"page":"337-339","source":"Crossref","is-referenced-by-count":32,"title":["Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7722-6321","authenticated-orcid":false,"given":"Wesley J.","family":"Hoffmann","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of California Davis Medical Center  Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"McHardy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology University of California\u2013Davis  Davis CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-5750","authenticated-orcid":false,"suffix":"III","given":"George R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology University of California\u2013Davis  Davis CA USA"},{"name":"Department of Internal Medicine Division of Infectious Diseases University of California Davis Medical Center  Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw360"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.7.1862"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00705-08"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.4.707"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/521259"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ancard.2014.05.007"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00021208"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90339-F"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.01.010"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00760-17"},{"key":"e_1_2_4_12_1","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1210\/endo.132.6.8504732","article-title":"Licorice inhibits 11 beta\u2010hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action","volume":"132","author":"Whorwood CB","year":"1993","journal-title":"Endocrinology"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200112000-00003"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1340267"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(96)90025-9"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110243251706"},{"key":"e_1_2_4_17_1","unstructured":"Itraconazole [package insert]. (Sempera) product monograph. Janssen\u2010Cilag GmbH Neuss Germany 2003."}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12749","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T07:31:54Z","timestamp":1695022314000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,15]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/myc.12749"],"URL":"https:\/\/doi.org\/10.1111\/myc.12749","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,15]]}}}