{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:14:30Z","timestamp":1761581670585,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Summary<\/jats:title>Invasive aspergillosis (IA<\/jats:styled-content>) is a life\u2010threatening infection affecting haematological cancer patients with chemotherapy\u2010induced neutropenia. The diagnosis of IA<\/jats:styled-content> often relies on the detection of galactomannan (GM<\/jats:styled-content>) in serum or bronchoalveolar lavage fluid (BAL<\/jats:styled-content>). Bi\u2010weekly serum GM<\/jats:styled-content> screening has been proposed for a pre\u2010emptive therapeutic approach of IA<\/jats:styled-content> in patients not receiving mold\u2010active prophylaxis. We have analysed all IA<\/jats:styled-content> cases among patients with haematological malignancies and prolonged chemotherapy\u2010induced neutropenia (>14\u00a0days) in our institution over a 10\u2010year period (2007\u20102017). Serum GM<\/jats:styled-content> was measured twice weekly and mold\u2010active prophylaxis was not routinely administered. Thirty IA<\/jats:styled-content> cases were observed and a positive serum GM<\/jats:styled-content> was the first indicator of IA<\/jats:styled-content> in 10 (33%) of them, which represents a need of approximately 500 GM<\/jats:styled-content> tests for the detection of a single IA<\/jats:styled-content> case. In the other 20 (67%) cases, suggestive chest CT<\/jats:styled-content> lesion was the first sign of IA<\/jats:styled-content> and bronchoscopy was required in 15 (50%) cases with negative serum GM<\/jats:styled-content> for establishing the diagnosis of probable\/proven IA<\/jats:styled-content>. A positive serum GM<\/jats:styled-content> was associated with a worse prognosis (57% 12\u2010week survival vs 100% among serum GM<\/jats:styled-content>\u2010negative patients, P<\/jats:italic>\u00a0=\u00a0.006), irrespective of the timing of GM<\/jats:styled-content> positivity compared to CT<\/jats:styled-content>. We concluded that bi\u2010weekly serum GM<\/jats:styled-content> screening demonstrated limited benefit in this population.<\/jats:p>","DOI":"10.1111\/myc.12755","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T10:06:44Z","timestamp":1518862004000},"page":"350-354","source":"Crossref","is-referenced-by-count":12,"title":["Role of bi\u2010weekly serum galactomannan screening for the diagnosis of invasive aspergillosis in haematological cancer patients"],"prefix":"10.1111","volume":"61","author":[{"given":"Jade","family":"Couchepin","sequence":"first","affiliation":[{"name":"Infectious Diseases Service Department of Medicine Lausanne University Hospital Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0387-6334","authenticated-orcid":false,"given":"Anne\u2010Sophie","family":"Brunel","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Department of Medicine Lausanne University Hospital Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8944-7295","authenticated-orcid":false,"given":"Katia","family":"Jaton","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Lausanne University Hospital Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Meylan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Department of Medicine Lausanne University Hospital Lausanne Switzerland"},{"name":"Institute of Microbiology Lausanne University Hospital Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Yves","family":"Bochud","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Department of Medicine Lausanne University Hospital Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1023-5597","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Lamoth","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Department of Medicine Lausanne University Hospital Lausanne Switzerland"},{"name":"Institute of Microbiology Lausanne University Hospital Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx030"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0488"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/503427"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01159-9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2508"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/343804"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065776"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/444462"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu673"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix130"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.15.152"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2011.09.011"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks208"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12755","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T10:49:49Z","timestamp":1695034189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,14]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/myc.12755"],"URL":"https:\/\/doi.org\/10.1111\/myc.12755","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"type":"print","value":"0933-7407"},{"type":"electronic","value":"1439-0507"}],"subject":[],"published":{"date-parts":[[2018,3,14]]}}}