{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:03:28Z","timestamp":1792134208395,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We studied 23 clinical and environmental strains of <jats:italic>Sporothrix schenckii<\/jats:italic> sensu <jats:italic>lato<\/jats:italic> collected from 1984 to 2017 in Argentina. The molecular identification (partial sequencing of a fragment of the calmodulin gene) of the strains was performed. For the yeast and mycelial phases, the in vitro susceptibility testing by a microdilution reference method was determined against eight antifungal drugs. Strains studied were identified as <jats:italic>S.\u00a0schenckii<\/jats:italic> sensu stricto 13 (56.5%), <jats:italic>S.\u00a0brasiliensis<\/jats:italic> 8 (34.7%) and <jats:italic>S.\u00a0globosa<\/jats:italic> 2 (8.7%). The most active antifungal drugs tested for the yeast and mycelial phases expressed as geometric mean (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) value of the minimal inhibitory concentration (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>) (\u03bcg\u00a0mL<jats:sup>\u22121<\/jats:sup>) were terbinafine (0.07 and 0.24), posaconazole (0.13 and 0.58), itraconazole (0.38 and 1.10) and ketoconazole (0.22 and 0.89), while fluconazole (110.10 and 131.92) and flucytosine (2.96 and 79.03) were the less active. For voriconazole and amphotericin B the <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> values were acceptably low for the yeast phase (0.39 and 0.72\u00a0\u03bcg\u00a0mL<jats:sup>\u22121<\/jats:sup>), while the mycelial phase showed values \u22652\u2010fold higher (8.76 and 1.88\u00a0\u03bcg\u00a0mL<jats:sup>\u22121<\/jats:sup>), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05. Here, we described <jats:italic>S.\u00a0schenckii<\/jats:italic> sensu stricto<jats:italic>, S.\u00a0brasiliensis<\/jats:italic> and <jats:italic>S.\u00a0globosa,<\/jats:italic> these species were isolated from humans, animals and soil and are circulating in Argentina since at least 1984.<\/jats:p>","DOI":"10.1111\/myc.12760","type":"journal-article","created":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T08:52:41Z","timestamp":1520067161000},"page":"441-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Molecular identification and susceptibility profile of <i>Sporothrix schenckii<\/i> sensu <i>lato<\/i> isolated in Argentina"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1991-2400","authenticated-orcid":false,"given":"Susana","family":"C\u00f3rdoba","sequence":"first","affiliation":[{"name":"Departamento Micolog\u00eda Instituto Nacional de Enfermedades Infecciosas \u201cDr. C. G. Malbr\u00e1n\u201d  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermina","family":"Isla","sequence":"additional","affiliation":[{"name":"Departamento Micolog\u00eda Instituto Nacional de Enfermedades Infecciosas \u201cDr. C. G. Malbr\u00e1n\u201d  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Szusz","sequence":"additional","affiliation":[{"name":"Departamento Micolog\u00eda Instituto Nacional de Enfermedades Infecciosas \u201cDr. C. G. Malbr\u00e1n\u201d  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Vivot","sequence":"additional","affiliation":[{"name":"Departamento Micolog\u00eda Instituto Nacional de Enfermedades Infecciosas \u201cDr. C. G. Malbr\u00e1n\u201d  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Hevia","sequence":"additional","affiliation":[{"name":"Departamento Micolog\u00eda Instituto Nacional de Enfermedades Infecciosas \u201cDr. C. G. Malbr\u00e1n\u201d  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Davel","sequence":"additional","affiliation":[{"name":"Departamento Micolog\u00eda Instituto Nacional de Enfermedades Infecciosas \u201cDr. C. G. Malbr\u00e1n\u201d  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina E.","family":"Canteros","sequence":"additional","affiliation":[{"name":"Departamento Micolog\u00eda Instituto Nacional de Enfermedades Infecciosas \u201cDr. C. G. Malbr\u00e1n\u201d  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myu062"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005638"},{"key":"e_1_2_9_4_1","first-page":"428","article-title":"Intradermal test with sporotrichin in a community in the Sierra Norte de Puebla","volume":"57","author":"Bonifaz A","year":"2013","journal-title":"Dermatol Rev Mex"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/313607"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/345437"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2012001000006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1726-46342011000300016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00007-11"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0903.020208"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/522765"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2003.00953.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-010-9380-8"},{"key":"e_1_2_9_14_1","unstructured":"Clinical and Laboratory Standards Institute.Reference method for broth dilution antifungal susceptibility testing of yeasts; Fourth Informational Supplement. 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