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Therefore, rational use of antifungal agents is important for optimal patient care and resource use. The study's objective was to analyse antifungal usage in a German tertiary teaching hospital, department of haematology and oncology, to evaluate quality of antifungal treatment and to assess the need for an antifungal stewardship programme. This retrospective observational study included patients \u226518\u00a0years receiving systemic antifungals for prophylaxis or therapy of invasive fungal infection between January and June 2016. Appropriateness of antifungal prescriptions was evaluated in accordance with guidelines of the German Society of Haematology and Oncology (<jats:styled-content style=\"fixed-case\">DGHO<\/jats:styled-content>) and drug labelling. In total, 104\/1278 (8.1%) patients received antifungals. One hundred seventy\u2010one antifungals were prescribed: 48 for prophylaxis, 104 for empirical and 19 for targeted therapy. In 127 (74.3%) prescriptions, indication was appropriate, and in 132 (77.2%), choice of drug. Antifungals were correctly dosed in 131 prescriptions (76.6%). Thirty\u2010four antifungals (20.0%) were co\u2010administrated with interacting drugs (5 mild to moderate, 29 severe interactions). Results of this analysis demonstrate that use of systemic antifungals in routine care differs in a substantial number of patients from guideline and labelling recommendations. To optimise antifungal use, the implementation of antifungal stewardship programmes seems to be justified.<\/jats:p>","DOI":"10.1111\/myc.12768","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T13:42:10Z","timestamp":1521985330000},"page":"464-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antifungal treatment in haematological and oncological patients: Need for quality assessment in routine care"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1507-9789","authenticated-orcid":false,"given":"Sarah J.","family":"Lachenmayr","sequence":"first","affiliation":[{"name":"Department of Haematology\/Oncology University Hospital of Munich Munich Germany"},{"name":"Department of Pharmacy University Hospital of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4649-0255","authenticated-orcid":false,"given":"Sophie","family":"Berking","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology University Hospital of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Horns","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology University Hospital of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothea","family":"Strobach","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University Hospital of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Ostermann","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology University Hospital of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology University Hospital of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1007\/978-3-319-04220-6_2"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1016\/S0002-9343(01)01130-5"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1016\/S1473-3099(17)30304-3"},{"key":"e_1_2_9_5_1","first-page":"1068","article-title":"The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM\u20102004 study","volume":"91","author":"Pagano L","year":"2006","journal-title":"Haematologica"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1086\/522189"},{"unstructured":"Robert Koch Institut.Bericht zum Krebsgeschehen in Deutschland;2016.http:\/\/www.krebsdaten.de\/Krebs\/DE\/Content\/Publikationen\/Krebsgeschehen\/Krebsgeschehen_node.html. 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