{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:17:45Z","timestamp":1783732665341,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We report our experience with the use of (1,3)\u2010\u00df\u2010<jats:sc>d<\/jats:sc>\u2010glucan (<jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content>) screening for the diagnosis of invasive aspergillosis (<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>) in neutropenic patients with haematological malignancies. The performance of <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> screening was assessed retrospectively in <jats:italic>per patient<\/jats:italic> and <jats:italic>per sample<\/jats:italic> analyses. Overall, 20 among 167 patients developed <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> (12%). In the <jats:italic>per patient<\/jats:italic> analysis, <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> showed 60% sensitivity and 78% specificity when the criterion for positivity was the presence of at least one <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> value \u226580\u00a0pg\/mL. For 2 consecutive positive results, sensitivity decreased to 40%, while specificity increased to 93% and was similar to that of a positive galactomannan (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>; 90%). The highest specificity (97%) was observed for combined positivity of at least one <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> and at least one <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>. In the <jats:italic>per sample<\/jats:italic> analysis, the specificity of <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> was 100% in the best scenario, 96% in the median scenario and 89% in the worst scenario. <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> became positive before <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> in 33% of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> patients with both markers positive (n\u00a0=\u00a012). Despite good specificity for 2 consecutive positive results, the <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> test offered unsatisfactory performance for the diagnosis of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> due to low sensitivity. The combination of <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> showed the potential for increasing specificity.<\/jats:p>","DOI":"10.1111\/myc.12787","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T10:59:33Z","timestamp":1524653973000},"page":"650-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Performance of serum (1,3)\u2010\u00df\u2010<scp>d<\/scp>\u2010glucan screening for the diagnosis of invasive aspergillosis in neutropenic patients with haematological malignancies"],"prefix":"10.1111","volume":"61","author":[{"given":"Elisa","family":"Furfaro","sequence":"first","affiliation":[{"name":"Department Health Sciences (DISSAL) University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Roberto","family":"Giacobbe","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Department Health Sciences (DISSAL) Ospedale Policlinico San Martino \u2010 IRCCS per l'Oncologia University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Del Bono","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Department Health Sciences (DISSAL) Ospedale Policlinico San Martino \u2010 IRCCS per l'Oncologia University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Signori","sequence":"additional","affiliation":[{"name":"Department Health Sciences (DISSAL) University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Guolo","sequence":"additional","affiliation":[{"name":"Clinic of Haematology Department of Internal Medicine (DiMI) Ospedale Policlinico San Martino \u2010 IRCCS per l'Oncologia University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Minetto","sequence":"additional","affiliation":[{"name":"Clinic of Haematology Department of Internal Medicine (DiMI) Ospedale Policlinico San Martino \u2010 IRCCS per l'Oncologia University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marino","family":"Clavio","sequence":"additional","affiliation":[{"name":"Clinic of Haematology Department of Internal Medicine (DiMI) Ospedale Policlinico San Martino \u2010 IRCCS per l'Oncologia University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Ballerini","sequence":"additional","affiliation":[{"name":"Clinic of Haematology Department of Internal Medicine (DiMI) Ospedale Policlinico San Martino \u2010 IRCCS per l'Oncologia University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gobbi","sequence":"additional","affiliation":[{"name":"Clinic of Haematology Department of Internal Medicine (DiMI) Ospedale Policlinico San Martino \u2010 IRCCS per l'Oncologia University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Viscoli","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Department Health Sciences (DISSAL) Ospedale Policlinico San Martino \u2010 IRCCS per l'Oncologia University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-4602","authenticated-orcid":false,"given":"Malgorzata","family":"Mikulska","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Department Health Sciences (DISSAL) Ospedale Policlinico San Martino \u2010 IRCCS per l'Oncologia University of Genoa  Genoa 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