{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T08:06:36Z","timestamp":1775721996429,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:label\/><jats:p>Patients with haematological malignancies are at risk for invasive fungal diseases (<jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content>). A survey was conducted in all Dutch academic haematology centres on their current diagnostic, prophylactic and therapeutic approach towards <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> in the context of azole\u2010resistance. In all 8 centres, a haematologist and microbiologist filled in the questionnaire that focused on different subgroups of haematology patients. Fungal prophylaxis during neutropaenia was directed against <jats:italic>Candida<\/jats:italic> and consisted of fluconazole and\/or amphotericin B suspension. Mould\u2010active prophylaxis was given to acute myeloid leukaemia patients during chemotherapy in 2 of 8 centres. All centres used azole prophylaxis in a subset of patients with graft\u2010versus\u2010host disease. A uniform approach towards the diagnosis and treatment of <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> and in particular azole\u2010resistant <jats:italic>Aspergillus fumigatus<\/jats:italic> was lacking. In 2017, all centres agreed to implement a uniform diagnostic and treatment algorithm regarding invasive aspergillosis with a central role for comprehensive diagnostics and <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010based detection of azole\u2010resistance. This study (<jats:styled-content style=\"fixed-case\">DB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content> 002) will re\u2010evaluate this algorithm when 280 patients have been treated. A heterogeneous approach towards antifungal prophylaxis, diagnosis and treatment was apparent in the Netherlands. Facing triazole\u2010resistance, consensus was reached on the implementation of a uniform diagnostic approach in all 8 centres.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.12788","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T05:51:27Z","timestamp":1524549087000},"page":"656-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The diagnosis and treatment of invasive aspergillosis in Dutch haematology units facing a rapidly increasing prevalence of azole\u2010resistance. A nationwide survey and rationale for the <scp>DB<\/scp>\u2010<scp>MSG<\/scp> 002 study protocol"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3224-3969","authenticated-orcid":false,"given":"Alexander F. A. D.","family":"Schauwvlieghe","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Section of Infectious Diseases Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Department of Haematology VU University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infection Control VU University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul E.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Center of Expertise in Mycology Radboudumc\/CWZ  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger J.","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart J.","family":"Biemond","sequence":"additional","affiliation":[{"name":"Department of Haematology Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldert","family":"Bart","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology (CINIMA) Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"von dem Borne","sequence":"additional","affiliation":[{"name":"Department of Haematology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelies","family":"Verbon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section of Infectious Diseases Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha T.","family":"van der Beek","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid M. P.","family":"Demandt","sequence":"additional","affiliation":[{"name":"Department of Haematology Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy J.","family":"Oudhuis","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan J.","family":"Cornelissen","sequence":"additional","affiliation":[{"name":"Department of Haematology Erasmus MC Cancer Institute  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter J. F. M.","family":"van der Velden","sequence":"additional","affiliation":[{"name":"Department of Haematology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lambert F. R.","family":"Span","sequence":"additional","affiliation":[{"name":"Department of Haematology University of Groningen University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greetje A.","family":"Kampinga","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology University of Groningen University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke H.","family":"Bruns","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alieke G.","family":"Vonk","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter\u2013Jan A.","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette K.","family":"Doorduijn","sequence":"additional","affiliation":[{"name":"Department of Haematology Erasmus MC Cancer Institute  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart J. A.","family":"Rijnders","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section of Infectious Diseases Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-627323"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/595846"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00520-17"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12440"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1710.110226"},{"key":"e_1_2_7_7_1","unstructured":"deGreeffSC MoutonJW.NethMap 2017: Consumption of antimicrobial agents and antimicrobial resistance among medically important bacteria in the Netherlands\/ MARAN 2017: Monitoring of antimicrobial resistance and antibiotic usage in animals in the Netherlands in 2016 Nethmap \/ Maran 2017. Rijksinstituut voor Volksgezondheid en Milieu RIVM."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit320"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw323"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201612-2540LE"},{"key":"e_1_2_7_11_1","unstructured":"European Society of Clinical Microbiology and Infectious Diseases\/European Fungal Infection Study Group.European Conference on Infections in Leukemia 5; primary antifungal prophylaxis.https:\/\/www.ebmt.org\/Contents\/Resources\/Library\/ECIL\/Documents\/2014%20ECIL5\/ECIL5antifungalprophylaxis%20%2020062014%20Final.pdf. Accessed January 22 2018."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-7-199304010-00003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki440"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061094"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061098"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/515128"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2006.00805.x"},{"key":"e_1_2_7_18_1","first-page":"CD000239","article-title":"Amphotericin B versus fluconazole for controlling fungal infections in neutropenic cancer patients","author":"Johansen HK","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.06.019"},{"key":"e_1_2_7_20_1","unstructured":"Dutch Working Party on Antibiotic Policy.SWAB Guidelines for the management of Invasive Fungal Infections.http:\/\/www.swab.nl\/richtlijnen. Accessed January 22 2018."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx031"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2015.02.023"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/586739"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_2_7_25_1","first-page":"CD007394","article-title":"Galactomannan detection for invasive aspergillosis in immunocompromised patients","author":"Leeflang MM","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2015.08.001"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01092-06"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031801"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv177"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03216-14"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.152900"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx029"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200704-606OC"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku364"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02479-16"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12759"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2014.06.001"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00931-09"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv380"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2017.03.005"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T04:09:35Z","timestamp":1695010175000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,13]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/myc.12788"],"URL":"https:\/\/doi.org\/10.1111\/myc.12788","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,13]]},"assertion":[{"value":"2017-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}