{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:33:12Z","timestamp":1790346792110,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Although standard itraconazole pulse therapy is a well\u2010established regimen for toenail onychomycosis, the cure rate for onychomycosis remains low. To evaluate the efficacy and safety of different cycles of itraconazole pulse therapy, determine the optimal dosage and number of cycles for onychomycosis. A total of 90 outpatients of our hospital with onychomycosis were randomised into three treatment groups: (1) standard itraconazole pulse therapy (200\u00a0mg twice per day, 1\u00a0week each month for three pulses); (2) long\u2010term pulse therapy (200\u00a0mg twice per day, 1\u00a0week each month for six pulses); (3) low\u2010dose and long\u2010term pulse therapy (200\u00a0mg\/d, 1\u00a0week per month for six pulses) and were followed up for 15\u00a0months. Of the initial patients, the trial was completed by 81 patients. The complete cure rates were 32.43% for three cycles and 75% for six cycles (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001). For six cycles, despite the administration of half\u2010dose for patients weighing no more than 55\u00a0kg, there was no statistical difference in the complete cure rate (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.862). Long\u2010term therapy is effective and safe for the treatment of toenail onychomycosis. For patients weighing no more than 55\u00a0kg, long\u2010term half\u2010dose itraconazole pulse therapy is recommended .\n                  <\/jats:p>","DOI":"10.1111\/myc.12799","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T07:39:50Z","timestamp":1528789190000},"page":"736-742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["An exploration of the optimum dosage and number of cycles of itraconazole pulse therapy for severe onychomycosis"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3656-3430","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Shanghai Tenth People's Hospital Tongji University School of Medicine  Shanghai 200072 P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Tenth People's Hospital Tongji University School of Medicine  Shanghai 200072 P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Tenth People's Hospital Tongji University School of Medicine  Shanghai 200072 P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Tenth People's Hospital Tongji University School of Medicine  Shanghai 200072 P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjiao","family":"Tao","sequence":"additional","affiliation":[{"name":"Dermatology Zhangjiagang second people's hospital  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Tenth People's Hospital Tongji University School of Medicine  Shanghai 200072 P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475417716362"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2001.00645.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05728.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01618.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05242.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13392"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630701243418"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12127"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2006.01351.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.d01-1175.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0056-2"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70074-4"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2000.00551.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00206.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01543.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.39.6.471.473"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3314\/jjmm.45.143"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1998.tb00762.x"},{"key":"e_1_2_5_20_1","first-page":"149","article-title":"Clinical hepatotoxicity associated with antifungal agents","volume":"16","author":"Kyriakidis I","year":"2017","journal-title":"Expert Opin Drug Saf"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.03.021"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00496.x"},{"key":"e_1_2_5_23_1","first-page":"6","article-title":"Update on the safety of itraconazole pulse therapy in onychomycosis and dermatomycoses","volume":"11","author":"Gupta A","year":"2001","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_24_1","article-title":"Safety of itraconazole pulse therapy for onychomycosis. 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