{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:55:52Z","timestamp":1789631752451,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    \u2010specific IgG is pivotal in making the diagnosis of chronic pulmonary aspergillosis (\n                    <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content>\n                    ). However, the cut\u2010off value for\n                    <jats:italic>A.\u00a0fumigatus<\/jats:italic>\n                    \u2010specific IgG remains unknown. We included consecutive treatment\u2010na\u00efve subjects with chronic cavitary pulmonary aspergillosis (\n                    <jats:styled-content style=\"fixed-case\">CCPA<\/jats:styled-content>\n                    , cases). The controls were subjects with treated pulmonary tuberculosis, who had residual radiological abnormality and minimal symptoms. The diagnosis of\n                    <jats:styled-content style=\"fixed-case\">CCPA<\/jats:styled-content>\n                    was based on consistent clinicoradiological features along with demonstration of\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    infection (growth of\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    in sputum or bronchoalveolar lavage fluid [\n                    <jats:styled-content style=\"fixed-case\">BALF<\/jats:styled-content>\n                    ] culture; serum or\n                    <jats:styled-content style=\"fixed-case\">BALF<\/jats:styled-content>\n                    galactomannan index &gt;0.5 and &gt;1, respectively). For determining the cut\u2010off of\n                    <jats:italic>A.\u00a0fumigatus<\/jats:italic>\n                    \u2010specific IgG (Phadia), subjects were randomly classified as derivation (two\u2010thirds) and validation (one\u2010third) cohort. One hundred and thirty\u2010seven cases and 50 controls were included. The best cut\u2010off value for\n                    <jats:italic>A.\u00a0fumigatus<\/jats:italic>\n                    \u2010specific IgG (derivation cohort) was 27.3\u00a0mgA\/L (\n                    <jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content>\n                    , 0.976) at a sensitivity and specificity of 95.6% and 100%, respectively. Using a cut\u2010off of 27\u00a0mgA\/L, the sensitivity and specificity in the validation cohort was 91.3% and 100%, respectively. In contrast, the sensitivity of\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    precipitins was only 25.5%. At a cut\u2010off value of 27\u00a0mgA\/L,\n                    <jats:italic>A.\u00a0fumigatus<\/jats:italic>\n                    \u2010specific IgG is a reliable test with high sensitivity and specificity in the diagnosis of\n                    <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content>\n                    . More studies are required to confirm our findings.\n                  <\/jats:p>","DOI":"10.1111\/myc.12815","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T14:53:53Z","timestamp":1529420033000},"page":"770-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Diagnostic cut\u2010off of\n                    <i>Aspergillus fumigatus<\/i>\n                    \u2010specific IgG in the diagnosis of chronic pulmonary aspergillosis"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6505-6019","authenticated-orcid":false,"given":"Inderpaul Singh","family":"Sehgal","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansraj","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahajal","family":"Dhooria","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh Nath","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2547-7668","authenticated-orcid":false,"given":"Ritesh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.01.002"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00583-2015"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/376526"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.11.089441"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114745"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2018.01.001"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.11.003"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12133"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.067546"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.5459"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myy024"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12075"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw444"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2009.01548.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.01.005"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2012.682228"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1974.tb28200.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2018.04.009"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myy012"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12541"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12815","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T04:43:28Z","timestamp":1694925808000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,12]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/myc.12815"],"URL":"https:\/\/doi.org\/10.1111\/myc.12815","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,12]]},"assertion":[{"value":"2018-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}