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Generally, <jats:italic>Aspergillus<\/jats:italic> spp. and <jats:italic>Fusarium<\/jats:italic> spp. are common in tropical and subtropical regions and <jats:italic>Candida<\/jats:italic> spp. are dominant in temperate areas. Demonstration of fungal elements in microscopic examination besides the isolation of fungi in culture is the gold standard of laboratory diagnosis. As the culture is a time\u2010consuming procedure, other approaches such as in vivo confocal microscopy which produces real\u2010time imaging of corneal tissue and molecular techniques have been developed to facilitate rapid diagnosis of fungal keratitis. The first choice of treatment is topical natamycin, although topical amphotericin B is the best choice for <jats:italic>Aspergillus<\/jats:italic> and <jats:italic>Candida<\/jats:italic> keratitis. Regarding the diversity of fungal aetiology and the emergence of drug resistance in some genera and species, proper identification using molecular methods and antifungal susceptibility testing could provide useful data. Furthermore, as the better efficacy of combination therapy in comparison to monotherapy is reported, in vitro determination of interactions between various drugs seem informative. This review aims to provide a general and updated view on the aetiology, risk factors, epidemiology, clinical and laboratory diagnosis, and management of fungal keratitis.<\/jats:p>","DOI":"10.1111\/myc.12822","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T08:36:28Z","timestamp":1531298188000},"page":"916-930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":217,"title":["Fungal keratitis: An overview of clinical and laboratory aspects"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0421-8659","authenticated-orcid":false,"given":"Shahram","family":"Mahmoudi","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology and Mycology School of Public Health Tehran University of Medical Sciences  Tehran Iran"},{"name":"Students\u2019 Scientific Research Center Tehran University of Medical Sciences  Tehran 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