{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:15:18Z","timestamp":1777518918768,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T00:00:00Z","timestamp":1537660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["9121353003"],"award-info":[{"award-number":["9121353003"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Dihydroxyacid dehydratase (<jats:styled-content style=\"fixed-case\">DHAD<\/jats:styled-content>) is a key enzyme in biosynthetic pathway of isoleucine and valine. This pathway is absent in human but exists in various organisms such as fungi. Using <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010seq analysis in this study, we identified <jats:italic><jats:styled-content style=\"fixed-case\">MGL<\/jats:styled-content>_3741<\/jats:italic>gene which encodes <jats:styled-content style=\"fixed-case\">DHAD<\/jats:styled-content> protein in <jats:italic>Malassezia globosa<\/jats:italic> (<jats:italic>M.\u00a0globosa<\/jats:italic>). Furthermore, we found that mentioned gene is homologous to the <jats:italic>Ustilago maydis<\/jats:italic>,<jats:italic> Saccharomyces cerevisiae<\/jats:italic>,<jats:italic> Aspergillus flavus<\/jats:italic>, and <jats:italic>Aspergillus fumigatus <\/jats:italic><jats:styled-content style=\"fixed-case\">ILV<\/jats:styled-content>3P. For understanding the probable role of this gene in pathogenicity of <jats:italic>M.\u00a0globosa,<\/jats:italic> we applied Real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> to investigate the differentially expressed of the <jats:italic><jats:styled-content style=\"fixed-case\">MGL<\/jats:styled-content>_3741<\/jats:italic> gene in healthy and pathogenic states. Our results indicate a significant difference between two mentioned stats. These results revealed that <jats:italic><jats:styled-content style=\"fixed-case\">ILV<\/jats:styled-content>3<\/jats:italic>\u2010like gene in <jats:italic>M.\u00a0globosa<\/jats:italic> can be related to the pathogenicity of this yeast.<\/jats:p>","DOI":"10.1111\/myc.12840","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T10:04:36Z","timestamp":1534241076000},"page":"938-944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i><scp>MGL<\/scp>_3741<\/i> gene contributes to pathogenicity of <i>Malassezia globosa<\/i> in pityriasis versicolor"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9275-7128","authenticated-orcid":false,"given":"Sanaz","family":"Aghaei Gharehbolagh","sequence":"first","affiliation":[{"name":"Department of Medical Mycology &amp; Parasitology School of Public Health Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parivash","family":"Kordbacheh","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology &amp; Parasitology School of Public Health Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Jamal","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology &amp; Parasitology School of Public Health Tehran University of Medical Sciences  Tehran Iran"},{"name":"Food Microbiology Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5320-5323","authenticated-orcid":false,"given":"Roshanak","family":"Daie Ghazvini","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology &amp; Parasitology School of Public Health Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazdan","family":"Asgari","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology School of Advanced Technologies in Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setareh","family":"Agha Kuchak Afshari","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology &amp; Parasitology School of Public Health Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6194-7447","authenticated-orcid":false,"given":"Seyedmojtaba","family":"Seyedmousavi","sequence":"additional","affiliation":[{"name":"Invasive Fungi Research Center Mazandaran University of Medical Sciences  Sari Iran"},{"name":"Center of Expertise in Microbiology Infection Biology and Antimicrobial Pharmacology  Tehran Iran"},{"name":"Department of Medical Microbiology Center of Expertise in Mycology Radboudumc\/CWZ  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sassan","family":"Rezaie","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology &amp; Parasitology School of Public Health Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.7.3022-3027.2003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.9.4253-4260.2004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.28501-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328342f787"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myu010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000600011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof1010013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-005-0297-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043559"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26928-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvj057"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.4.767"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.67.1.1-15.2003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02135-09"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.5.5.816-824.2006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.034348-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins6113187"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-16-S6-S3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq256"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2011.02345.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00673.x"},{"key":"e_1_2_7_23_1","unstructured":"1990 Academic Press Inc San Diego Calif TJ White T Bruns S Lee S Tailor MA Innins DH Gelfand JJ Sninsky TJ White Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics. 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