{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:50:12Z","timestamp":1773402612636,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T00:00:00Z","timestamp":1537660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Screening for Aspergillus (Asp\u2010AG<\/jats:styled-content>) and Candida antigen (Ca\u2010AG<\/jats:styled-content>) with immunoassays is established for stem cell recipients at high risk for invasive fungal infections (IFI<\/jats:styled-content>). While parenteral nutrition (PN<\/jats:styled-content>) will be applied in case of complications leading to insufficient alimentation, piperacillin\u2010tazobactam (TZP<\/jats:styled-content>) is started at the onset of febrile neutropenia.<\/jats:p><\/jats:sec>Objectives<\/jats:title>The aim of this study was to investigate drug\u2010laboratory interactions between PN<\/jats:styled-content> and TZP<\/jats:styled-content> and both immunoassays which could affect the specificity of the assays and lead to the false assumption of an IFI<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Batches of TZP<\/jats:styled-content> and PN<\/jats:styled-content> were tested with both assays in vitro. In total, 380 samples of 83 batches were analysed.<\/jats:p><\/jats:sec>Results<\/jats:title>None of the examined preparations were tested positive with Asp\u2010AG<\/jats:styled-content> assay. Measurable amounts of Ca\u2010AG<\/jats:styled-content> were detected in a lipid emulsion, two different trace element supplements, a fat\u2010soluble vitamin preparation and all tested brands of TZP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We conclude that false positivity of Asp\u2010AG<\/jats:styled-content> assay due to TZP<\/jats:styled-content> and PN<\/jats:styled-content> does not occur. Cross reactions with Ca\u2010AG<\/jats:styled-content> assay have been detected in some preparations. The in vivo relevance of Ca\u2010AG<\/jats:styled-content> positivity has to be reviewed in further studies considering an effect of dilution. Physicians should be aware of a possible cross reaction with Ca\u2010AG<\/jats:styled-content> assays which could lead to false\u2010positive results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.12841","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T22:05:08Z","timestamp":1534284308000},"page":"931-937","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In vitro detection of Candida and Aspergillus antigen in parenteral nutrition and fixed combinations of piperacillin\u2010tazobactam"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1800-2330","authenticated-orcid":false,"given":"Wencke","family":"Walter","sequence":"first","affiliation":[{"name":"Klinik\u2010Apotheke Universit\u00e4tsklinikum Carl Gustav Carus an der Technischen Universit\u00e4t Dresden Dresden 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