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However, there are different methods to evaluate fluconazole<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s and comparative analysis among such techniques and their comprehensive correlation with clinical outcome are not available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Over a 13\u2010year period (2000\u20102013), fluconazole<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s were determined for 62 cryptococcal isolates recovered from 22 patients with cryptococcosis using<jats:styled-content style=\"fixed-case\">CLSI<\/jats:styled-content>M27\u2010A3,<jats:styled-content style=\"fixed-case\">EUCAST<\/jats:styled-content>,<jats:italic>E<\/jats:italic>test and Sensititre YeastOne, simultaneously. The relationship between the fluconazole<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s and the clinical outcome at week 10 was assessed in patients who received fluconazole as induction or maintenance therapy (n\u00a0=\u00a016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The percentage of cryptococcal strains with<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>values \u226516\u00a0\u03bcg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>according to different methods was<jats:styled-content style=\"fixed-case\">CLSI<\/jats:styled-content>1.6%,<jats:styled-content style=\"fixed-case\">EUCAST<\/jats:styled-content>16.1%,<jats:italic>E<\/jats:italic>test 31.6% and Sensititre YeastOne 53.2%. Among the 16 patients treated with fluconazole, no correlation between clinical outcome and any<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>value obtained with either method was observed. The only variable independently associated with a poor outcome was having a disseminated disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a weak correlation between fluconazole<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s against<jats:italic>Cryptococcus<\/jats:italic>spp. as determined by<jats:styled-content style=\"fixed-case\">CLSI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">EUCAST<\/jats:styled-content>,<jats:italic>E<\/jats:italic>test and Sensititre YeastOne. Neither procedure could predict the clinical outcome of patients with cryptococcosis receiving fluconazole\u2010based therapy. With present methods, fluconazole resistance in<jats:italic>Cryptococcus<\/jats:italic>may be clinically misleading.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.12847","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T17:18:10Z","timestamp":1536167890000},"page":"441-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Fluconazole resistance is not a predictor of poor outcome in patients with cryptococcosis"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0697-3992","authenticated-orcid":false,"given":"Antonio","family":"Vena","sequence":"first","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Medicine Department School of Medicine 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