{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T02:33:03Z","timestamp":1778293983392,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive mucormycosis is a rare but frequently fatal fungal disease. The acute and rapidly progressive evolution causes unfavourable outcome in 22%\u201059% of patients and its treatment represents a clinical challenge, especially in immunocompromised patients. Current data in paediatric oncological patients are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The infection Working Group of the Italian Association of Pediatric Hematology and Oncology (<jats:styled-content style=\"fixed-case\">AIEOP<\/jats:styled-content>) analysed the episodes of invasive mucormycosis occurred between 2009 and 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Fifteen cases of proven mucormycosis (male\/female 8\/7; median age 14.1\u00a0years, range 7.7\u201018.6) were reported after chemotherapy for acute leukaemia and lymphoma (12) and allogeneic stem cell transplantation (3). The aetiology was <jats:italic>Rhizopus oryzae<\/jats:italic> 4, <jats:italic>Lichtheimia corymbifera<\/jats:italic> 3 and <jats:italic>Mucor spp<\/jats:italic>. 8.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Paranasal sinus was the primary site of infection in 14\/15 patients combined with orbital involvement (9), central nervous system (8), lung (4), thyroid gland and kidney (1). All patients received liposomal Amphotericin B (L\u2010AmB) (3\u201010\u00a0mg\/kg), with surgical debridement in 14\/15 cases. Eleven patients received maintenance treatment with posaconazole (9) or isavuconazole (2). Eight out of fifteen patients (53.3%) died, after 3\u20106\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mucormycosis involved mainly the sinu\u2010orbital site and affected children &gt;10\u00a0years. Despite aggressive treatment with high\u2010dose L\u2010AmB and timely surgical debridement, the mortality rate remains still high.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.12862","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T06:13:48Z","timestamp":1539929628000},"page":"165-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Invasive mucormycosis in children with cancer: A retrospective study from the Infection Working Group of Italian Pediatric Hematology Oncology Association"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8813-3200","authenticated-orcid":false,"given":"Paola","family":"Muggeo","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology and Hematology University Hospital of Policlinico, Bari  Bari 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Hospital of Policlinico, Bari  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Colombini","sequence":"additional","affiliation":[{"name":"Ematologia Pediatrica Fondazione MBBM Ospedale San Gerardo  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fara","family":"Petruzziello","sequence":"additional","affiliation":[{"name":"Emato\u2010Oncologia pediatrica AO Santobono\u2010Pausillipon  Napoli Itlay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0431-3197","authenticated-orcid":false,"given":"Katia","family":"Perruccio","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Oncology Azienda Ospedaliera Universitaria, Ospedale Santa Maria della Misericordia  Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Berger","sequence":"additional","affiliation":[{"name":"Pediatric Onco\u2010Hematology Stem Cell 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