{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:52:11Z","timestamp":1773982331663,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["40400520128"],"award-info":[{"award-number":["40400520128"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Summary<\/jats:title>Paracoccidioidomycosis (PCM<\/jats:styled-content>) is a granulomatous disease caused by fungi of the species complex of the Paracoccidioides<\/jats:italic> genus. One of the main clinical manifestations of PCM<\/jats:styled-content> is the presence of oral lesions with the presence of epithelioid granulomas. In this work, we aimed to evaluate the frequency of SNP<\/jats:styled-content>s in the TNF<\/jats:styled-content>\u2010<\/jats:italic>\u03b1, JAK<\/jats:styled-content>1<\/jats:italic>, VDR<\/jats:styled-content>, DC<\/jats:styled-content>\u2010SIGN<\/jats:styled-content><\/jats:italic> and Fc<\/jats:italic>\u03b3RII<\/jats:styled-content>a<\/jats:italic> genes in patients with chronic PCM<\/jats:styled-content> and verify possible association of these SNP<\/jats:styled-content>s with the organisation pattern of the granulomas in the oral lesions. A total of 66 samples of DNA<\/jats:styled-content> were obtained from oral lesions biopsies and 106 DNA<\/jats:styled-content> samples were obtained from healthy individuals. The individuals were genotyped for SNP<\/jats:styled-content>s in DC<\/jats:styled-content>\u2010SIGN<\/jats:styled-content><\/jats:italic> (rs4804803), Fc<\/jats:italic>\u03b3RII<\/jats:styled-content>a<\/jats:italic> (rs1801274), JAK<\/jats:styled-content>1<\/jats:italic> (rs11208534), TNF<\/jats:styled-content>\u2010<\/jats:italic>\u03b1 (rs1800629) and VDR<\/jats:styled-content><\/jats:italic> (rs7975232) by real\u2010time PCR<\/jats:styled-content> and allele discrimination method. Granulomas were classified as loose or dense according to the histological pattern. In the VDR<\/jats:styled-content><\/jats:italic> (rs7975232), the CC<\/jats:styled-content> genotype (P<\/jats:italic>\u00a0<\u00a00.001, OR<\/jats:styled-content>\u00a0=\u00a05.94, 95% CI<\/jats:styled-content>\u00a0=\u00a02.07\u201017.05), and the C allele (P<\/jats:italic>\u00a0=\u00a00.027, OR<\/jats:styled-content>\u00a0=\u00a02.71, 95% CI<\/jats:styled-content>\u00a0=\u00a01.07\u20106.86), as well as the GG<\/jats:styled-content> genotype in DC<\/jats:styled-content>\u2010SIGN<\/jats:styled-content><\/jats:italic> (rs4804803) (P<\/jats:italic>\u00a0=\u00a00.032, OR: 3.76, 95%, I<\/jats:italic>\u00a0=\u00a01.06\u201013.38) are associated with an increased risk of oral PCM<\/jats:styled-content>. Our data indicate that VDR<\/jats:styled-content><\/jats:italic> and DC<\/jats:styled-content>\u2010SIGN<\/jats:styled-content><\/jats:italic> genetics variations are related to the susceptibility of oral PCM<\/jats:styled-content> in the group of patients analysed.<\/jats:p>","DOI":"10.1111\/myc.12866","type":"journal-article","created":{"date-parts":[[2018,10,27]],"date-time":"2018-10-27T05:02:37Z","timestamp":1540616557000},"page":"186-192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["DC<\/scp>\u2010SIGN<\/scp><\/i> and VDR<\/scp><\/i> polymorphisms are associated with chronic form of paracoccidioidomycosis with oral manifestations"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9861-3275","authenticated-orcid":false,"given":"Tertuliano","family":"Alves Pereira Neto","sequence":"first","affiliation":[{"name":"Departamento de Microbiologia e Imunologia Universidade Federal de Alfenas Alfenas MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro Ant\u00f4nio","family":"Costa Pereira","sequence":"additional","affiliation":[{"name":"Departamento de Patologia e Parasitologia Universidade Federal de Alfenas Alfenas MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Adolfo","family":"Costa Hanemann","sequence":"additional","affiliation":[{"name":"Faculdade de Odontologia Universidade Federal de Alfenas Alfenas MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Felipe Leomil","family":"Coelho","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia e Imunologia Universidade Federal de Alfenas Alfenas MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Cosme Cotta","family":"Malaquias","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia e Imunologia Universidade Federal de Alfenas Alfenas MG 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