{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T06:23:51Z","timestamp":1791699831589,"version":"4.3.4"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T00:00:00Z","timestamp":1543104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,3]]},"abstract":"Summary<\/jats:title>\n \n Objectives<\/jats:title>\n \n Bronchoalveolar lavage galactomannan (\n BAL<\/jats:styled-content>\n \u2010\n GM<\/jats:styled-content>\n ) is a mycological criterion for diagnosis of probable invasive aspergillosis (\n IA<\/jats:styled-content>\n ) per European Organization for Research and Treatment of Cancer\/Mycoses Study Group (\n EORT<\/jats:styled-content>\n \u2010\n MSG<\/jats:styled-content>\n ) consensus criteria, but its real\u2010world positive predictive value (\n PPV<\/jats:styled-content>\n ) has not been well\u2010studied. Our aim was to estimate the\n PPV<\/jats:styled-content>\n of\n BAL<\/jats:styled-content>\n \u2010\n GM<\/jats:styled-content>\n in a contemporary cohort of patients with positive\n BAL<\/jats:styled-content>\n \u2010\n GM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We identified consecutive patients with \u22651 positive\n BAL<\/jats:styled-content>\n \u2010\n GM<\/jats:styled-content>\n value (index\u00a0\u2265\u00a00.5) at Brigham and Women's Hospital from 11\/2009 to 3\/2016. We classified patients as having no, possible, probable, or proven\n IA<\/jats:styled-content>\n , excluding\n BAL<\/jats:styled-content>\n \u2010\n GM<\/jats:styled-content>\n as mycological criterion.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We studied 134 patients: 54% had hematologic malignancy (\n HM<\/jats:styled-content>\n ), and 10% were solid organ transplant (\n SOT<\/jats:styled-content>\n ) recipients. A total of 42% of positive (\u22650.5)\n BAL<\/jats:styled-content>\n \u2010\n GM<\/jats:styled-content>\n results were falsely positive (\n PPV<\/jats:styled-content>\n 58%). The number of probable\n IA<\/jats:styled-content>\n cases was increased by 23% using positive\n BAL<\/jats:styled-content>\n \u2010\n GM<\/jats:styled-content>\n as mycologic criterion alone.\n PPV<\/jats:styled-content>\n was higher in patients with\n HM<\/jats:styled-content>\n or\n SOT<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u00a0<\u00a00.001) and with use of higher thresholds for positivity (\n BAL<\/jats:styled-content>\n \u2010\n GM<\/jats:styled-content>\n \u00a0\u2265\u00a01 vs 1\u20100.8 vs 0.8\u20100.5:\n P<\/jats:italic>\n \u00a0=\u00a00.002).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n 42% of positive\n BAL<\/jats:styled-content>\n \u2010\n GM<\/jats:styled-content>\n values were falsely positive. We propose a critical reassessment of\n BAL<\/jats:styled-content>\n \u2010\n GM<\/jats:styled-content>\n cutoff values in different patient populations. Accurate noninvasive tests for diagnosis of\n IA<\/jats:styled-content>\n are urgently needed.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/myc.12867","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T21:08:06Z","timestamp":1541106486000},"page":"204-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["False positive bronchoalveolar lavage galactomannan: Effect of host and cut\u2010off value"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-108X","authenticated-orcid":false,"given":"Dimitrios","family":"Farmakiotis","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Rhode Island Hospital Warren Alpert Medical School of Brown University Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rhode Island Hospital Warren Alpert Medical School of Brown University Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rhode Island Hospital Warren Alpert Medical School of Brown University Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Ismail","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Rhode Island Hospital Division of Infectious Diseases Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Kubiak","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Rhode Island Hospital Division of Infectious Diseases Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Koo","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Rhode Island Hospital Division of Infectious Diseases Harvard Medical School Boston 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