{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T01:17:33Z","timestamp":1774142253102,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007431","name":"Neurosciences Research Foundation","doi-asserted-by":"publisher","award":["2016R1D1A1A09918488"],"award-info":[{"award-number":["2016R1D1A1A09918488"]}],"id":[{"id":"10.13039\/100007431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Superficial fungal infections are one of the most common and burdensome skin problems affecting quality of life in patients. Various conventional antifungal agents have been used to treat fungal infections; however, various problems have been reported including drug interaction, drug resistance and low effectiveness. Efinaconazole is a novel antifungal agent, which has proven to be particularly effective against onychomycosis compared with conventional antifungal agents. However, the antifungal efficacy of Efinaconazole for specific strains has not been analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We conducted an in\u2010vitro study to measure the antifungal activity of Efinaconazole against strains of <jats:italic>Trichophyton rubrum<\/jats:italic>,<jats:italic> Trichophyton mentagrophytes<\/jats:italic> and <jats:italic>Candida albicans<\/jats:italic> compared with widely\u2010used antifungal drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We obtained strains of <jats:italic>T. rubrum, T. mentagrophytes<\/jats:italic> and <jats:italic>C. albicans<\/jats:italic> isolated from patients with onychomycosis and tinea pedis. The minimal inhibitory concentration (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>) for various strains of fungal species was evaluated for the antifungal susceptibility test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Efinaconazole showed a low <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> against almost strains of dermatophytes and <jats:italic>C<\/jats:italic>\u00a0<jats:italic>albicans<\/jats:italic> and also presented low resistance, indicating high potency of efinaconazole for treatment of superficial fungal infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Efinaconazole could be a comparable alternative to replace existing conventional agents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.12870","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T12:05:21Z","timestamp":1542197121000},"page":"291-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of drug susceptibility test for Efinaconazole compared with conventional antifungal agents"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8354-9618","authenticated-orcid":false,"given":"Min Seok","family":"Hur","sequence":"first","affiliation":[{"name":"Department of Dermatology Konkuk University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minji","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Systems Biotechnology Chung\u2010Ang University  Anseong Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Hee","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Systems Biotechnology Chung\u2010Ang University  Anseong Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1268-1248","authenticated-orcid":false,"given":"Yang Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Konkuk University School of Medicine  Seoul Korea"},{"name":"Research Institute of Medical Science Konkuk University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof4030099"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.149.s65.4.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)81262-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-008-9099-y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)81282-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1556\/AMicr.48.2001.3-4.15"},{"issue":"12","key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1080\/19424396.2000.12223143","article-title":"Candidiasis: pathogenesis, clinical characteristics, and treatment","volume":"28","author":"Appleton SS","year":"2000","journal-title":"J Calif Dent Assoc"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.6.811"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80351-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-90-10-495"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.3.353"},{"key":"e_1_2_7_13_1","first-page":"1","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi, Approved Standard","author":"John HR","year":"2002"},{"key":"e_1_2_7_14_1","unstructured":"WayneP.Clinical and Laboratory Standards Institute: Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard. 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